C25.4 Malignant neoplasm of endocrine pancreas

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applicable to

• Malignant neoplasm of islets of Langerhans

Use additional code

• code to identify any functional activity.

Applies from C25 Malignant neoplasm of pancreas

Use additional code

• code to identify:
• alcohol abuse and dependence (F10.-)

Code also

• if applicable exocrine pancreatic insufficiency (K86.81)

Risk adjustment (HCC)

• CMS-HCC V28: HCC 20 — Lung and Other Severe Cancers
• CMS-HCC V22: HCC 9 — Lung and Other Severe Cancers
• RxHCC V08: HCC 20 — Lung, Kidney, and Other Cancers; Secondary Cancer of Lymph Nodes and Other Sites
• ESRD V24: HCC 9

MS-DRG index

Defines the logic of DRG(s) 435-437 in MDC 07.

Approximate ICD-9-CM (GEMs)

• 157.4 Malignant neoplasm of islets of langerhans

Code annotations containing back-references to C25.4

Back-references to C25.4

• Type 1 Excludes: C75 Malignant neoplasm of other endocrine glands and related structures ("malignant neoplasm of endocrine pancreas (C25.4)")
• Type 1 Excludes: C75 Malignant neoplasm of other endocrine glands and related structures ("malignant neoplasm of islets of Langerhans (C25.4)")
• Type 2 Excludes: C7A Malignant neuroendocrine tumors ("malignant pancreatic islet cell tumors (C25.4)")

Diagnosis Index entries for C25.4

• Adenocarcinoma › islet cell › pancreas
• Adenocarcinoma › islet cell › unspecified site
• Carcinoma (malignant) › islet cell › pancreas
• Carcinoma (malignant) › islet cell › unspecified site
• Gastrinoma › malignant › pancreas
• Gastrinoma › malignant › unspecified site
• Glucagonoma › pancreas › malignant
• Glucagonoma › unspecified site › malignant
• Insulinoma › pancreas › malignant
• Insulinoma › unspecified site › malignant
• Tumor › alpha-cell › malignant › pancreas
• Tumor › alpha-cell › malignant › unspecified site
• Tumor › beta-cell › malignant › pancreas
• Tumor › beta-cell › malignant › unspecified site
• Tumor › G cell › malignant › pancreas
• Tumor › G cell › malignant › unspecified site
• Tumor › islet cell › malignant › pancreas
• Tumor › islet cell › malignant › unspecified site

Nearby codes

• C25 Malignant neoplasm of pancreas
• C25.0 Malignant neoplasm of head of pancreas
• C25.1 Malignant neoplasm of body of pancreas
• C25.2 Malignant neoplasm of tail of pancreas
• C25.3 Malignant neoplasm of pancreatic duct
• C25.4 Malignant neoplasm of endocrine pancreas (this code)
• C25.7 Malignant neoplasm of other parts of pancreas
• C25.8 Malignant neoplasm of overlapping sites of pancreas
• C25.9 Malignant neoplasm of pancreas, unspecified