C45.0 Mesothelioma of pleura

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Excludes1 (never code together)

• other malignant neoplasm of pleura (C38.4)

Risk adjustment (HCC)

• CMS-HCC V28: HCC 19 — Myelodysplastic Syndromes, Multiple Myeloma, and Other Cancers
• CMS-HCC V22: HCC 9 — Lung and Other Severe Cancers
• RxHCC V08: HCC 22 — Prostate, Breast, Bladder, and Other Cancers and Tumors
• ESRD V24: HCC 9

MS-DRG index

Defines the logic of DRG(s) 180-182 in MDC 04.

Approximate ICD-9-CM (GEMs)

• 163.9 Malignant neoplasm of pleura, unspecified (approximate)

Code annotations containing back-references to C45.0

Back-references to C45

• Type 1 Excludes: C38 Malignant neoplasm of heart, mediastinum and pleura ("mesothelioma (C45.-)")
• Type 1 Excludes: C48 Malignant neoplasm of retroperitoneum and peritoneum ("mesothelioma (C45.-)")
• Type 2 Excludes: C49 Malignant neoplasm of other connective and soft tissue ("mesothelioma (C45.-)")

Diagnosis Index entries for C45.0

• Mesothelioma (malignant) › site classification › pleura
• Mesothelioma (malignant) › site classification › pleura › parietal

Nearby codes

• C45 Mesothelioma
• C45.0 Mesothelioma of pleura (this code)
• C45.1 Mesothelioma of peritoneum
• C45.2 Mesothelioma of pericardium
• C45.7 Mesothelioma of other sites
• C45.9 Mesothelioma, unspecified