C75.8 Malignant neoplasm with pluriglandular involvement, unspecified

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applies from C75 Malignant neoplasm of other endocrine glands and related structures

Excludes1 (never code together)

• malignant carcinoid tumors (C7A.0-)
• malignant neoplasm of adrenal gland (C74.-)
• malignant neoplasm of endocrine pancreas (C25.4)
• malignant neoplasm of islets of Langerhans (C25.4)
• malignant neoplasm of ovary (C56.-)
• malignant neoplasm of testis (C62.-)
• malignant neoplasm of thymus (C37)
• malignant neoplasm of thyroid gland (C73)
• malignant neuroendocrine tumors (C7A.-)

Risk adjustment (HCC)

• CMS-HCC V28: HCC 23 — Prostate, Breast, and Other Cancers and Tumors
• CMS-HCC V22: HCC 12 — Breast, Prostate, and Other Cancers and Tumors
• RxHCC V08: HCC 22 — Prostate, Breast, Bladder, and Other Cancers and Tumors
• ESRD V24: HCC 12

MS-DRG index

Defines the logic of DRG(s) 643-645 in MDC 10.

Approximate ICD-9-CM (GEMs)

• 194.8 Malignant neoplasm of other endocrine glands and related structures

Code annotations containing back-references to C75.8

Back-references to C75

• Code First: Z15.0 Genetic susceptibility to malignant neoplasm (", if applicable, any current malignant neoplasm (C00-C75, C81-C96)")

Nearby codes

• C75.1 Malignant neoplasm of pituitary gland
• C75.2 Malignant neoplasm of craniopharyngeal duct
• C75.3 Malignant neoplasm of pineal gland
• C75.4 Malignant neoplasm of carotid body
• C75.5 Malignant neoplasm of aortic body and other paraganglia
• C75.8 Malignant neoplasm with pluriglandular involvement, unspecified (this code)
• C75.9 Malignant neoplasm of endocrine gland, unspecified