C81.27 Mixed cellularity Hodgkin lymphoma, spleen

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applies from C81 Hodgkin lymphoma

Excludes1 (never code together)

• personal history of Hodgkin lymphoma (Z85.71)

Applies from C81.2 Mixed cellularity Hodgkin lymphoma

Applicable to

• Mixed cellularity classical Hodgkin lymphoma

Risk adjustment (HCC)

• CMS-HCC V28: HCC 21 — Lymphoma and Other Cancers
• CMS-HCC V22: HCC 10 — Lymphoma and Other Cancers
• RxHCC V08: HCC 21 — Lymphomas and Other Hematologic Cancers
• ESRD V24: HCC 10

MS-DRG index

Defines the logic of DRG(s) 820-822 in MDC 17.

Approximate ICD-9-CM (GEMs)

• 201.67 Hodgkin's disease, mixed cellularity, spleen

Code annotations containing back-references to C81.27

Back-references to C81

• Type 1 Excludes: C26.1 Malignant neoplasm of spleen ("Hodgkin lymphoma (C81.-)")
• Type 1 Excludes: C76 Malignant neoplasm of other and ill-defined sites ("malignant neoplasm of lymphoid, hematopoietic and related tissue (C81-C96)")
• Type 1 Excludes: C77 Secondary and unspecified malignant neoplasm of lymph nodes ("malignant neoplasm of lymph nodes, specified as primary (C81-C86, C88, C96.-)")
• Code First: Z15.0 Genetic susceptibility to malignant neoplasm (", if applicable, any current malignant neoplasm (C00-C75, C81-C96)")

Nearby codes

• C81.22 Mixed cellularity Hodgkin lymphoma, intrathoracic lymph nodes
• C81.23 Mixed cellularity Hodgkin lymphoma, intra-abdominal lymph nodes
• C81.24 Mixed cellularity Hodgkin lymphoma, lymph nodes of axilla and upper limb
• C81.25 Mixed cellularity Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
• C81.26 Mixed cellularity Hodgkin lymphoma, intrapelvic lymph nodes
• C81.27 Mixed cellularity Hodgkin lymphoma, spleen (this code)
• C81.28 Mixed cellularity Hodgkin lymphoma, lymph nodes of multiple sites
• C81.29 Mixed cellularity Hodgkin lymphoma, extranodal and solid organ sites
• C81.2A Mixed cellularity Hodgkin lymphoma, in remission
• C81.3 Lymphocyte depleted Hodgkin lymphoma
• C81.30 Lymphocyte depleted Hodgkin lymphoma, unspecified site