C81.49 Lymphocyte-rich Hodgkin lymphoma, extranodal and solid organ sites

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applies from C81 Hodgkin lymphoma

Excludes1 (never code together)

• personal history of Hodgkin lymphoma (Z85.71)

Applies from C81.4 Lymphocyte-rich Hodgkin lymphoma

Applicable to

• Lymphocyte-rich classical Hodgkin lymphoma

Excludes1 (never code together)

• nodular lymphocyte predominant Hodgkin lymphoma (C81.0-)

Risk adjustment (HCC)

• CMS-HCC V28: HCC 21 — Lymphoma and Other Cancers
• CMS-HCC V22: HCC 10 — Lymphoma and Other Cancers
• RxHCC V08: HCC 21 — Lymphomas and Other Hematologic Cancers
• ESRD V24: HCC 10

MS-DRG index

Defines the logic of DRG(s) 820-822 in MDC 17.

Approximate ICD-9-CM (GEMs)

• 201.40 Hodgkin's disease, lymphocytic-histiocytic predominance, unspecified site, extranodal and solid organ sites (approximate)

Code annotations containing back-references to C81.49

Back-references to C81

• Type 1 Excludes: C26.1 Malignant neoplasm of spleen ("Hodgkin lymphoma (C81.-)")
• Type 1 Excludes: C76 Malignant neoplasm of other and ill-defined sites ("malignant neoplasm of lymphoid, hematopoietic and related tissue (C81-C96)")
• Type 1 Excludes: C77 Secondary and unspecified malignant neoplasm of lymph nodes ("malignant neoplasm of lymph nodes, specified as primary (C81-C86, C88, C96.-)")
• Code First: Z15.0 Genetic susceptibility to malignant neoplasm (", if applicable, any current malignant neoplasm (C00-C75, C81-C96)")

Nearby codes

• C81.44 Lymphocyte-rich Hodgkin lymphoma, lymph nodes of axilla and upper limb
• C81.45 Lymphocyte-rich Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
• C81.46 Lymphocyte-rich Hodgkin lymphoma, intrapelvic lymph nodes
• C81.47 Lymphocyte-rich Hodgkin lymphoma, spleen
• C81.48 Lymphocyte-rich Hodgkin lymphoma, lymph nodes of multiple sites
• C81.49 Lymphocyte-rich Hodgkin lymphoma, extranodal and solid organ sites (this code)
• C81.4A Lymphocyte-rich Hodgkin lymphoma, in remission
• C81.7 Other Hodgkin lymphoma
• C81.70 Other Hodgkin lymphoma, unspecified site
• C81.71 Other Hodgkin lymphoma, lymph nodes of head, face, and neck
• C81.72 Other Hodgkin lymphoma, intrathoracic lymph nodes