D80.4 Selective deficiency of immunoglobulin M [IgM]

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Risk adjustment (HCC)

• CMS-HCC V28: HCC 115 — Specified Immunodeficiencies and White Blood Cell Disorders
• CMS-HCC V22: HCC 47 — Disorders of Immunity
• RxHCC V08: HCC 99 — Immune Disorders
• ESRD V24: HCC 47

MS-DRG index

Defines the logic of DRG(s) 814-816 in MDC 16.

Approximate ICD-9-CM (GEMs)

• 279.02 Selective IgM immunodeficiency

Code annotations containing back-references to D80.4

Back-references to D80

• Type 1 Excludes: D72 Other disorders of white blood cells ("immunity disorders (D80-D89)")
• Type 1 Excludes: D84.81 Immunodeficiency due to conditions classified elsewhere ("certain disorders involving the immune mechanism (D80-D83, D84.0, D84.1, D84.9)")
• Code First: M36.8 Systemic disorders of connective tissue in other diseases classified elsewhere ("hypogammaglobulinemia (D80.-)")

Diagnosis Index entries for D80.4

• Absence (of) (organ or part) (complete or partial) › immunoglobulin, isolated NEC › IgM
• Deficiency, deficient › immunity › IgM
• Deficiency, deficient › immunoglobulin, selective › M (IgM)
• Immunodeficiency › selective, immunoglobulin › M (IgM)

Nearby codes

• D80 Immunodeficiency with predominantly antibody defects
• D80.0 Hereditary hypogammaglobulinemia
• D80.1 Nonfamilial hypogammaglobulinemia
• D80.2 Selective deficiency of immunoglobulin A [IgA]
• D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
• D80.4 Selective deficiency of immunoglobulin M [IgM] (this code)
• D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
• D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia
• D80.7 Transient hypogammaglobulinemia of infancy
• D80.8 Other immunodeficiencies with predominantly antibody defects
• D80.9 Immunodeficiency with predominantly antibody defects, unspecified