D81.32 Adenosine deaminase 2 deficiency

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applicable to

• ADA2 deficiency
• Adenosine deaminase deficiency type 2

Code also

• , if applicable, any associated manifestations, such as:
• polyarteritis nodosa (M30.0)
• stroke (I63.-)

Applies from D81 Combined immunodeficiencies

Excludes1 (never code together)

• autosomal recessive agammaglobulinemia (Swiss type) (D80.0)

Risk adjustment (HCC)

• CMS-HCC V28: HCC 114 — Common Variable and Combined Immunodeficiencies
• CMS-HCC V22: HCC 47 — Disorders of Immunity
• RxHCC V08: HCC 99 — Immune Disorders
• ESRD V24: HCC 47

MS-DRG index

Defines the logic of DRG(s) 642 in MDC 10.

Code annotations containing back-references to D81.32

Back-references to D81

• Type 1 Excludes: D72 Other disorders of white blood cells ("immunity disorders (D80-D89)")
• Type 1 Excludes: D84.81 Immunodeficiency due to conditions classified elsewhere ("certain disorders involving the immune mechanism (D80-D83, D84.0, D84.1, D84.9)")
• Type 1 Excludes: E79 Disorders of purine and pyrimidine metabolism ("combined immunodeficiency disorders (D81.-)")

Diagnosis Index entries for D81.32

• Deficiency, deficient › ADA2 (adenosine deaminase 2)
• Deficiency, deficient › adenosine deaminase (ADA) › type 2

Nearby codes

• D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
• D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
• D81.3 Adenosine deaminase [ADA] deficiency
• D81.30 Adenosine deaminase deficiency, unspecified
• D81.31 Severe combined immunodeficiency due to adenosine deaminase deficiency
• D81.32 Adenosine deaminase 2 deficiency (this code)
• D81.39 Other adenosine deaminase deficiency
• D81.4 Nezelof's syndrome
• D81.5 Purine nucleoside phosphorylase [PNP] deficiency
• D81.6 Major histocompatibility complex class I deficiency
• D81.7 Major histocompatibility complex class II deficiency