`D81.82` Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applicable to

p110d-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency [PASLI] disease

Code also

, if applicable, any associated manifestations, such as:
bronchiectasis (J47.-)
herpes virus infections (B00.-)
other acute respiratory tract infections (J00-J06; J20-J22)
other infections (A00-B99)
pneumonia (J12-J18)

Applies from D81 Combined immunodeficiencies

Excludes1 (never code together)

autosomal recessive agammaglobulinemia (Swiss type) (D80.0)

Risk adjustment (HCC)

CMS-HCC V28: HCC 114 — Common Variable and Combined Immunodeficiencies
CMS-HCC V22: HCC 47 — Disorders of Immunity
RxHCC V08: HCC 99 — Immune Disorders
ESRD V24: HCC 47

MS-DRG index

Defines the logic of DRG(s) 808-810 in MDC 16.

Code annotations containing back-references to D81.82

Back-references to D81

Type 1 Excludes: D72 Other disorders of white blood cells ("immunity disorders (D80-D89)")
Type 1 Excludes: D84.81 Immunodeficiency due to conditions classified elsewhere ("certain disorders involving the immune mechanism (D80-D83, D84.0, D84.1, D84.9)")
Type 1 Excludes: E79 Disorders of purine and pyrimidine metabolism ("combined immunodeficiency disorders (D81.-)")

Diagnosis Index entries for D81.82

Disease, diseased › p110d-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency [PASLI]
Syndrome › activated phosphoinositide 3-kinase delta syndrome [APDS]

Nearby codes

D81.8 Other combined immunodeficiencies
D81.81 Biotin-dependent carboxylase deficiency
D81.810 Biotinidase deficiency
D81.818 Other biotin-dependent carboxylase deficiency
D81.819 Biotin-dependent carboxylase deficiency, unspecified
D81.82 Activated Phosphoinositide 3-kinase Delta Syndrome [APDS] (this code)
D81.89 Other combined immunodeficiencies
D81.9 Combined immunodeficiency, unspecified