F32.1 Major depressive disorder, single episode, moderate

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applies from F32 Depressive episode

Includes

• single episode of agitated depression
• single episode of depressive reaction
• single episode of major depression
• single episode of psychogenic depression
• single episode of reactive depression
• single episode of vital depression

Excludes1 (never code together)

• bipolar disorder (F31.-)
• manic episode (F30.-)
• recurrent depressive disorder (F33.-)

Excludes2 (not included here)

• adjustment disorder (F43.2)

Risk adjustment (HCC)

• CMS-HCC V28: HCC 155 — Major Depression, Moderate or Severe, without Psychosis
• CMS-HCC V22: HCC 58 — Major Depressive, Bipolar, and Paranoid Disorders
• RxHCC V08: HCC 132 — Depression
• ESRD V24: HCC 59

MS-DRG index

Defines the logic of DRG(s) 885 in MDC 19.

Approximate ICD-9-CM (GEMs)

• 296.22 Major depressive affective disorder, single episode, moderate

Code annotations containing back-references to F32.1

Back-references to F32

• Type 2 Excludes: F06.3 Mood disorder due to known physiological condition ("mood disorders, not due to known physiological condition or unspecified (F30-F39)")
• Type 1 Excludes: F30 Manic episode ("major depressive disorder, single episode (F32.-)")
• Type 1 Excludes: F31 Bipolar disorder ("major depressive disorder, single episode (F32.-)")
• Type 2 Excludes: F42 Obsessive-compulsive disorder ("obsessive-compulsive symptoms occurring in depression (F32.-, F33.-)")
• Type 2 Excludes: F44.2 Dissociative stupor ("depressive stupor (F32, F33)")
• Type 2 Excludes: F63.2 Kleptomania ("depressive disorder with stealing (F31.-, F32.-, F33.-)")
• Type 2 Excludes: F90 Attention-deficit hyperactivity disorders ("mood [affective] disorders (F30-F39)")
• Type 2 Excludes: F91 Conduct disorders ("mood [affective] disorders (F30-F39)")
• Type 2 Excludes: F93.0 Separation anxiety disorder of childhood ("mood [affective] disorders (F30-F39)")
• Type 1 Excludes: R40.1 Stupor ("depressive stupor (F31.-, F32.-, F33.-)")
• Type 2 Excludes: R53.83 Other fatigue ("exhaustion and fatigue due to depressive episode (F32.-)")

Diagnosis Index entries for F32.1

• Disorder (of) › depressive › major › single episode › moderate
• Episode › depressive › major › moderate

Nearby codes

• F32 Depressive episode
• F32.0 Major depressive disorder, single episode, mild
• F32.1 Major depressive disorder, single episode, moderate (this code)
• F32.2 Major depressive disorder, single episode, severe without psychotic features
• F32.3 Major depressive disorder, single episode, severe with psychotic features
• F32.4 Major depressive disorder, single episode, in partial remission
• F32.5 Major depressive disorder, single episode, in full remission
• F32.8 Other depressive episodes