F53.0 Postpartum depression

Billable ICD-10-CM code, FY2026.

Applicable to

• Postnatal depression, NOS
• Postpartum depression, NOS

Applies from F53 Mental and behavioral disorders associated with the puerperium, not elsewhere classified

Excludes1 (never code together)

• mood disorders with psychotic features (F30.2, F31.2, F31.5, F31.64, F32.3, F33.3)
• postpartum dysphoria (O90.6)
• psychosis in schizophrenia, schizotypal, delusional, and other psychotic disorders (F20-F29)

Risk adjustment (HCC)

• RxHCC V08: HCC 132 — Depression

MS-DRG index

Defines the logic of DRG(s) 881 in MDC 19.

Medicare Code Edits (MCE v43.1 (April 2026))

• Maternity diagnoses (age 9 through 64): Age conflict edit. These diagnoses are clinically expected only in patients age 9 through 64.

Code annotations containing back-references to F53.0

Back-references to F53.0

• Type 1 Excludes: O90.6 Postpartum mood disturbance ("postpartum depression (F53.0)")

Diagnosis Index entries for F53.0

• Depression (acute) (mental) › postnatal (NOS)
• Depression (acute) (mental) › postpartum (NOS)
• Disorder (of) › mental (or behavioral) (nonpsychotic) › puerperal

Nearby codes

• F53 Mental and behavioral disorders associated with the puerperium, not elsewhere classified
• F53.0 Postpartum depression (this code)
• F53.1 Puerperal psychosis