G35.C1 Active secondary progressive multiple sclerosis

Billable ICD-10-CM code, FY2026.

Applicable to

• Secondary progressive multiple sclerosis with evidence of inflammatory disease activity

Risk adjustment (HCC)

• CMS-HCC V28: HCC 198 — Multiple Sclerosis
• CMS-HCC V22: HCC 77 — Multiple Sclerosis
• RxHCC V08: HCC 159 — Multiple Sclerosis
• ESRD V24: HCC 77

MS-DRG index

Defines the logic of DRG(s) 058-060 in MDC 01.

Code annotations containing back-references to G35.C1

Back-references to G35

• Code First: F02 Dementia in other diseases classified elsewhere ("multiple sclerosis (G35-)")
• Code First: F48.2 Pseudobulbar affect ("multiple sclerosis (G35-)")
• Type 2 Excludes: G04 Encephalitis, myelitis and encephalomyelitis ("multiple sclerosis (G35-)")
• Type 1 Excludes: G37.3 Acute transverse myelitis in demyelinating disease of central nervous system ("multiple sclerosis (G35-)")

Diagnosis Index entries for G35.C1

• Sclerosis, sclerotic › multiple (brain stem) (cerebral) (disseminated) (generalized) (spinal cord) › progressive › secondary › with › evidence of inflammatory disease activity
• Sclerosis, sclerotic › multiple (brain stem) (cerebral) (disseminated) (generalized) (spinal cord) › progressive › secondary › active

Nearby codes

• G35.B0 Primary progressive multiple sclerosis, unspecified
• G35.B1 Active primary progressive multiple sclerosis
• G35.B2 Non-active primary progressive multiple sclerosis
• G35.C Secondary progressive multiple sclerosis
• G35.C0 Secondary progressive multiple sclerosis, unspecified
• G35.C1 Active secondary progressive multiple sclerosis (this code)
• G35.C2 Non-active secondary progressive multiple sclerosis
• G35.D Multiple sclerosis, unspecified