I51.81 Takotsubo syndrome

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applicable to

• Reversible left ventricular dysfunction following sudden emotional stress
• Stress induced cardiomyopathy
• Takotsubo cardiomyopathy
• Transient left ventricular apical ballooning syndrome

Applies from I51 Complications and ill-defined descriptions of heart disease

Excludes2 (not included here)

• heart disease specified as rheumatic (I00-I09)

MS-DRG index

Defines the logic of DRG(s) 314-316 in MDC 05.

Approximate ICD-9-CM (GEMs)

• 429.83 Takotsubo syndrome

Code annotations containing back-references to I51.81

Back-references to I51.81

• Code First: I5A Non-ischemic myocardial injury (non-traumatic) ("takotsubo syndrome (I51.81)")

Diagnosis Index entries for I51.81

• Cardiomyopathy (familial) (idiopathic) › stress induced
• Cardiomyopathy (familial) (idiopathic) › takotsubo
• Dysfunction › left ventricular, following sudden emotional stress
• Dysfunction › ventricular › left, reversible, following sudden emotional stress
• Syndrome › apical ballooning (transient left ventricular)
• Syndrome › takotsubo
• Syndrome › transient left ventricular apical ballooning

Nearby codes

• I51.3 Intracardiac thrombosis, not elsewhere classified
• I51.4 Myocarditis, unspecified
• I51.5 Myocardial degeneration
• I51.7 Cardiomegaly
• I51.8 Other ill-defined heart diseases
• I51.81 Takotsubo syndrome (this code)
• I51.89 Other ill-defined heart diseases
• I51.9 Heart disease, unspecified