N46.021 Azoospermia due to drug therapy

Billable ICD-10-CM code, FY2026.

Applies from N46 Male infertility

Excludes1 (never code together)

• vasectomy status (Z98.52)

Applies from N46.0 Azoospermia

Applicable to

• Absolute male infertility
• Male infertility due to germinal (cell) aplasia
• Male infertility due to spermatogenic arrest (complete)

Applies from N46.02 Azoospermia due to extratesticular causes

Code also

• associated cause

MS-DRG index

Defines the logic of DRG(s) 729-730 in MDC 12.

Approximate ICD-9-CM (GEMs)

• 606.0 Azoospermia (approximate)

Medicare Code Edits (MCE v43.1 (April 2026))

• Adult diagnoses (age 15 through 124): Age conflict edit. These diagnoses are clinically expected only in patients age 15 through 124.

Code annotations containing back-references to N46.021

Back-references to N46.0

• Type 1 Excludes: E29 Testicular dysfunction ("azoospermia or oligospermia NOS (N46.0-N46.1)")
• Type 1 Excludes: R86 Abnormal findings in specimens from male genital organs ("azoospermia (N46.0-)")

Back-references to N46

• Type 2 Excludes: Z31 Encounter for procreative management ("male infertility (N46.-)")
• Type 1 Excludes: Z98.5 Sterilization status ("male infertility (N46.-)")

Diagnosis Index entries for N46.021

• Azoospermia (organic) › due to › drug therapy
• Infertility › male › azoospermia › extratesticular cause › drug therapy

Nearby codes

• N46 Male infertility
• N46.0 Azoospermia
• N46.01 Organic azoospermia
• N46.02 Azoospermia due to extratesticular causes
• N46.021 Azoospermia due to drug therapy (this code)
• N46.022 Azoospermia due to infection
• N46.023 Azoospermia due to obstruction of efferent ducts
• N46.024 Azoospermia due to radiation
• N46.025 Azoospermia due to systemic disease
• N46.029 Azoospermia due to other extratesticular causes