N46.121 Oligospermia due to drug therapy

Billable ICD-10-CM code, FY2026.

Applies from N46 Male infertility

Excludes1 (never code together)

• vasectomy status (Z98.52)

Applies from N46.1 Oligospermia

Applicable to

• Male infertility due to germinal cell desquamation
• Male infertility due to hypospermatogenesis
• Male infertility due to incomplete spermatogenic arrest

Applies from N46.12 Oligospermia due to extratesticular causes

Code also

• associated cause

MS-DRG index

Defines the logic of DRG(s) 729-730 in MDC 12.

Approximate ICD-9-CM (GEMs)

• 606.1 Oligospermia (approximate)

Medicare Code Edits (MCE v43.1 (April 2026))

• Adult diagnoses (age 15 through 124): Age conflict edit. These diagnoses are clinically expected only in patients age 15 through 124.

Code annotations containing back-references to N46.121

Back-references to N46.1

• Type 1 Excludes: E29 Testicular dysfunction ("azoospermia or oligospermia NOS (N46.0-N46.1)")
• Type 1 Excludes: R86 Abnormal findings in specimens from male genital organs ("oligospermia (N46.1-)")

Back-references to N46

• Type 2 Excludes: Z31 Encounter for procreative management ("male infertility (N46.-)")
• Type 1 Excludes: Z98.5 Sterilization status ("male infertility (N46.-)")

Diagnosis Index entries for N46.121

• Infertility › male › oligospermia › extratesticular cause › drug therapy
• Oligospermia › due to › drug therapy

Nearby codes

• N46.025 Azoospermia due to systemic disease
• N46.029 Azoospermia due to other extratesticular causes
• N46.1 Oligospermia
• N46.11 Organic oligospermia
• N46.12 Oligospermia due to extratesticular causes
• N46.121 Oligospermia due to drug therapy (this code)
• N46.122 Oligospermia due to infection
• N46.123 Oligospermia due to obstruction of efferent ducts
• N46.124 Oligospermia due to radiation
• N46.125 Oligospermia due to systemic disease
• N46.129 Oligospermia due to other extratesticular causes