O02.81 Inappropriate change in quantitative human chorionic gonadotropin (hCG) in early pregnancy

Billable ICD-10-CM code, FY2026.

Applicable to

• Biochemical pregnancy
• Chemical pregnancy
• Inappropriate level of quantitative human chorionic gonadotropin (hCG) for gestational age in early pregnancy

Applies from O02 Other abnormal products of conception

Excludes1 (never code together)

• papyraceous fetus (O31.0-)

Use additional code

• code from category O08 to identify any associated complication.

Applies from O02.8 Other specified abnormal products of conception

Excludes1 (never code together)

• abnormal products of conception with blighted ovum (O02.0)
• abnormal products of conception with hydatidiform mole (O01.-)
• abnormal products of conception with nonhydatidiform mole (O02.0)

MS-DRG index

Defines the logic of DRG(s) 817-819 in MDC 14.

Approximate ICD-9-CM (GEMs)

• 631.0 Inappropriate change in quantitative human chorionic gonadotropin (hCG) in early pregnancy

Medicare Code Edits (MCE v43.1 (April 2026))

• Maternity diagnoses (age 9 through 64): Age conflict edit. These diagnoses are clinically expected only in patients age 9 through 64.

Code annotations containing back-references to O02.81

Back-references to O02.8

• Type 1 Excludes: O02.1 Missed abortion ("missed abortion with other abnormal products of conception (O02.8-)")

Back-references to O02

• Type 1 Excludes: D65 Disseminated intravascular coagulation [defibrination syndrome] ("abortion or ectopic or molar pregnancy (O00-O07, O08.1)")
• Type 2 Excludes: D68 Other coagulation defects ("coagulation defects complicating abortion or ectopic or molar pregnancy (O00-O07, O08.1)")
• Type 1 Excludes: G08 Intracranial and intraspinal phlebitis and thrombophlebitis ("abortion, ectopic or molar pregnancy (O00-O07, O08.7)")
• Type 2 Excludes: I26 Pulmonary embolism ("pulmonary embolism complicating abortion, ectopic or molar pregnancy (O00-O07, O08.2)")
• Code First: I47 Paroxysmal tachycardia ("abortion or ectopic or molar pregnancy (O00-O07, O08.8)")
• Code First: I49 Other cardiac arrhythmias ("abortion or ectopic or molar pregnancy (O00-O07, O08.8)")
• Code First: I50 Heart failure ("heart failure complicating abortion or ectopic or molar pregnancy (O00-O07, O08.8)")
• Code First: I74 Arterial embolism and thrombosis ("embolism and thrombosis complicating abortion or ectopic or molar pregnancy (O00-O07, O08.2)")
• Code First: I80 Phlebitis and thrombophlebitis (", if applicable: phlebitis and thrombophlebitis complicating abortion, ectopic or molar pregnancy (O00-O07, O08.7)")
• Code First: I82 Other venous embolism and thrombosis ("abortion, ectopic or molar pregnancy (O00-O07, O08.7)")
• Type 1 Excludes: K65 Peritonitis ("peritonitis with or following abortion or ectopic or molar pregnancy (O00-O07, O08.0)")
• Type 2 Excludes: K72 Hepatic failure, not elsewhere classified ("hepatic failure complicating abortion or ectopic or molar pregnancy (O00-O07, O08.8)")
• Type 1 Excludes: O20 Hemorrhage in early pregnancy ("pregnancy with abortive outcome (O00-O08)")
• Type 1 Excludes: R34 Anuria and oliguria ("anuria and oliguria complicating abortion or ectopic or molar pregnancy (O00-O07, O08.4)")
• Type 1 Excludes: R55 Syncope and collapse ("shock complicating or following abortion or ectopic or molar pregnancy (O00-O07, O08.3)")
• Type 1 Excludes: R57 Shock, not elsewhere classified ("shock complicating or following ectopic or molar pregnancy (O00-O07, O08.3)")
• Type 1 Excludes: T79.0 Air embolism (traumatic) ("air embolism complicating abortion or ectopic or molar pregnancy (O00-O07, O08.2)")
• Type 1 Excludes: T79.1 Fat embolism (traumatic) ("abortion or ectopic or molar pregnancy (O00-O07, O08.2)")
• Type 1 Excludes: T79.4 Traumatic shock ("shock complicating abortion or ectopic or molar pregnancy (O00-O07, O08.3)")
• Type 1 Excludes: T81.1 Postprocedural shock ("shock following abortion or ectopic or molar pregnancy (O00-O07, O08.3)")
• Type 1 Excludes: T81.7 Vascular complications following a procedure, not elsewhere classified ("embolism complicating abortion or ectopic or molar pregnancy (O00-O07, O08.2)")

Diagnosis Index entries for O02.81

• Inappropriate › change in quantitative human chorionic gonadotropin (hCG) in early pregnancy
• Inappropriate › level of quantitative human chorionic gonadotropin (hCG) for gestational age in early pregnancy
• Pregnancy (single) (uterine) › biochemical
• Pregnancy (single) (uterine) › chemical

Nearby codes

• O02 Other abnormal products of conception
• O02.0 Blighted ovum and nonhydatidiform mole
• O02.1 Missed abortion
• O02.8 Other specified abnormal products of conception
• O02.81 Inappropriate change in quantitative human chorionic gonadotropin (hCG) in early pregnancy (this code)
• O02.89 Other abnormal products of conception
• O02.9 Abnormal product of conception, unspecified