O26.641 Intrahepatic cholestasis of pregnancy, first trimester

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applies from O26.6 Liver and biliary tract disorders in pregnancy, childbirth and the puerperium

Excludes2 (not included here)

• hepatorenal syndrome following labor and delivery (O90.41)

Use additional code

• code to identify the specific disorder

Applies from O26.64 Intrahepatic cholestasis of pregnancy

Use additional code

• code for hepatic obstruction (K76.89)

MS-DRG index

Defines the logic of DRG(s) 817-819 in MDC 14.

Medicare Code Edits (MCE v43.1 (April 2026))

• Maternity diagnoses (age 9 through 64): Age conflict edit. These diagnoses are clinically expected only in patients age 9 through 64.

Code annotations containing back-references to O26.641

Back-references to O26.6

• Type 2 Excludes: K72 Hepatic failure, not elsewhere classified ("hepatic failure complicating pregnancy, childbirth and the puerperium (O26.6-)")
• Type 2 Excludes: O99.6 Diseases of the digestive system complicating pregnancy, childbirth and the puerperium ("liver and biliary tract disorders in pregnancy, childbirth and the puerperium (O26.6-)")

Back-references to O26

• Type 1 Excludes: Z03.7 Encounter for suspected maternal and fetal conditions ruled out ("known or suspected fetal anomalies affecting management of mother, not ruled out (O26.-, O35.-, O36.-, O40.-, O41.-)")

Nearby codes

• O26.613 Liver and biliary tract disorders in pregnancy, third trimester
• O26.619 Liver and biliary tract disorders in pregnancy, unspecified trimester
• O26.62 Liver and biliary tract disorders in childbirth
• O26.63 Liver and biliary tract disorders in the puerperium
• O26.64 Intrahepatic cholestasis of pregnancy
• O26.641 Intrahepatic cholestasis of pregnancy, first trimester (this code)
• O26.642 Intrahepatic cholestasis of pregnancy, second trimester
• O26.643 Intrahepatic cholestasis of pregnancy, third trimester
• O26.649 Intrahepatic cholestasis of pregnancy, unspecified trimester
• O26.7 Subluxation of symphysis (pubis) in pregnancy, childbirth and the puerperium
• O26.71 Subluxation of symphysis (pubis) in pregnancy