O30.221 Quadruplet pregnancy with two or more monoamniotic fetuses, first trimester

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applies from O30 Multiple gestation

Code also

• any complications specific to multiple gestation

MS-DRG index

Defines the logic of DRG(s) 817-819 in MDC 14.

Approximate ICD-9-CM (GEMs)

• 651.21 Quadruplet pregnancy, delivered, with or without mention of antepartum condition (approximate)
• 651.23 Quadruplet pregnancy, antepartum condition or complication (approximate)
• V91.22 Quadruplet gestation, with two or more monoamniotic fetuses (approximate)

Medicare Code Edits (MCE v43.1 (April 2026))

• Maternity diagnoses (age 9 through 64): Age conflict edit. These diagnoses are clinically expected only in patients age 9 through 64.

Nearby codes

• O30.211 Quadruplet pregnancy with two or more monochorionic fetuses, first trimester
• O30.212 Quadruplet pregnancy with two or more monochorionic fetuses, second trimester
• O30.213 Quadruplet pregnancy with two or more monochorionic fetuses, third trimester
• O30.219 Quadruplet pregnancy with two or more monochorionic fetuses, unspecified trimester
• O30.22 Quadruplet pregnancy with two or more monoamniotic fetuses
• O30.221 Quadruplet pregnancy with two or more monoamniotic fetuses, first trimester (this code)
• O30.222 Quadruplet pregnancy with two or more monoamniotic fetuses, second trimester
• O30.223 Quadruplet pregnancy with two or more monoamniotic fetuses, third trimester
• O30.229 Quadruplet pregnancy with two or more monoamniotic fetuses, unspecified trimester
• O30.23 Quadruplet pregnancy, quadrachorionic/quadra-amniotic
• O30.231 Quadruplet pregnancy, quadrachorionic/quadra-amniotic, first trimester