O43.221 Placenta increta, first trimester

Billable ICD-10-CM code, FY2026.

Applies from O43 Placental disorders

Excludes2 (not included here)

• maternal care for poor fetal growth due to placental insufficiency (O36.5-)
• placenta previa (O44.-)
• placental polyp (O90.89)
• placentitis (O41.14-)
• premature separation of placenta [abruptio placentae] (O45.-)

Applies from O43.2 Morbidly adherent placenta

Excludes1 (never code together)

• retained placenta (O73.-)

Code also

• associated third stage postpartum hemorrhage, if applicable (O72.0)

MS-DRG index

Defines the logic of DRG(s) 769 in MDC 14.

Approximate ICD-9-CM (GEMs)

• 667.02 Retained placenta without hemorrhage, delivered, with mention of postpartum complication (approximate)
• 667.04 Retained placenta without hemorrhage, postpartum condition or complication (approximate)

Medicare Code Edits (MCE v43.1 (April 2026))

• Maternity diagnoses (age 9 through 64): Age conflict edit. These diagnoses are clinically expected only in patients age 9 through 64.

Code annotations containing back-references to O43.221

Back-references to O43.22

• Type 1 Excludes: O73 Retained placenta and membranes, without hemorrhage ("placenta increta (O43.22-)")

Back-references to O43.2

• Code Also: O72.0 Third-stage hemorrhage ("type of adherent placenta (O43.2-)")

Nearby codes

• O43.211 Placenta accreta, first trimester
• O43.212 Placenta accreta, second trimester
• O43.213 Placenta accreta, third trimester
• O43.219 Placenta accreta, unspecified trimester
• O43.22 Placenta increta
• O43.221 Placenta increta, first trimester (this code)
• O43.222 Placenta increta, second trimester
• O43.223 Placenta increta, third trimester
• O43.229 Placenta increta, unspecified trimester
• O43.23 Placenta percreta
• O43.231 Placenta percreta, first trimester