O45.021 Premature separation of placenta with disseminated intravascular coagulation, first trimester

Billable ICD-10-CM code, FY2026. Acts as a Major Complication or Comorbidity (MCC) as a secondary diagnosis.

MS-DRG index

Defines the logic of DRG(s) 817-819 in MDC 14.

Approximate ICD-9-CM (GEMs)

• 641.31 Antepartum hemorrhage associated with coagulation defects, delivered, with or without mention of antepartum condition (approximate)
• 641.33 Antepartum hemorrhage associated with coagulation defects, antepartum condition or complication (approximate)

Medicare Code Edits (MCE v43.1 (April 2026))

• Maternity diagnoses (age 9 through 64): Age conflict edit. These diagnoses are clinically expected only in patients age 9 through 64.

Code annotations containing back-references to O45.021

Back-references to O45.0

• Type 1 Excludes: D65 Disseminated intravascular coagulation [defibrination syndrome] ("pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3)")
• Type 2 Excludes: D68 Other coagulation defects ("coagulation defects complicating pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3)")

Back-references to O45

• Type 2 Excludes: O43 Placental disorders ("premature separation of placenta [abruptio placentae] (O45.-)")
• Type 1 Excludes: O46 Antepartum hemorrhage, not elsewhere classified ("premature separation of placenta [abruptio placentae] (O45.-)")
• Type 1 Excludes: O67 Labor and delivery complicated by intrapartum hemorrhage, not elsewhere classified ("premature separation of placenta [abruptio placentae] (O45.-)")
• Type 1 Excludes: O99.1 Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium ("hemorrhage with coagulation defects (O45.-, O46.0-, O67.0, O72.3)")

Nearby codes

• O45.011 Premature separation of placenta with afibrinogenemia, first trimester
• O45.012 Premature separation of placenta with afibrinogenemia, second trimester
• O45.013 Premature separation of placenta with afibrinogenemia, third trimester
• O45.019 Premature separation of placenta with afibrinogenemia, unspecified trimester
• O45.02 Premature separation of placenta with disseminated intravascular coagulation
• O45.021 Premature separation of placenta with disseminated intravascular coagulation, first trimester (this code)
• O45.022 Premature separation of placenta with disseminated intravascular coagulation, second trimester
• O45.023 Premature separation of placenta with disseminated intravascular coagulation, third trimester
• O45.029 Premature separation of placenta with disseminated intravascular coagulation, unspecified trimester
• O45.09 Premature separation of placenta with other coagulation defect
• O45.091 Premature separation of placenta with other coagulation defect, first trimester