Z15.01 Genetic susceptibility to malignant neoplasm of breast

Billable ICD-10-CM code, FY2026. Exempt from present-on-admission (POA) reporting.

Applies from Z15 Genetic susceptibility to disease

Includes

• confirmed abnormal gene

Excludes1 (never code together)

• chromosomal anomalies (Q90-Q99)

Use additional code

• code, if applicable, for any associated family history of the disease (Z80-Z84)

Applies from Z15.0 Genetic susceptibility to malignant neoplasm

Code first

• , if applicable, any current malignant neoplasm (C00-C75, C81-C96)

Use additional code

• code, if applicable, for any personal history of malignant neoplasm (Z85.-)

MS-DRG index

Defines the logic of DRG(s) 951 in MDC 23.

Approximate ICD-9-CM (GEMs)

• V84.01 Genetic susceptibility to malignant neoplasm of breast

Medicare Code Edits (MCE v43.1 (April 2026))

• Unacceptable principal diagnosis: These codes describe a circumstance which influences care but is not a current illness or injury, or capture only an underlying condition, and are unacceptable as principal diagnosis.

Code annotations containing back-references to Z15.01

Back-references to Z15.0

• Code Also: Q85.81 PTEN hamartoma tumor syndrome (", if applicable, genetic susceptibility to malignant neoplasm (Z15.0-)")
• Use Additional: Z79.81 Long term (current) use of agents affecting estrogen receptors and estrogen levels ("genetic susceptibility to malignant neoplasm (cancer) (Z15.0-)")

Back-references to Z15

• Use Additional: Z40.0 Encounter for prophylactic surgery for risk factors related to malignant neoplasms ("code to identify risk factor, such as genetic susceptibility to malignant neoplasm Z15.-")

Diagnosis Index entries for Z15.01

• Family, familial › Li-Fraumeni (syndrome)
• Genetic › susceptibility to disease NEC › malignant neoplasm › breast
• Susceptibility to disease, genetic › malignant neoplasm › breast
• Syndrome › Li-Fraumeni

Nearby codes

• Z15 Genetic susceptibility to disease
• Z15.0 Genetic susceptibility to malignant neoplasm
• Z15.01 Genetic susceptibility to malignant neoplasm of breast (this code)
• Z15.02 Genetic susceptibility to malignant neoplasm of ovary
• Z15.03 Genetic susceptibility to malignant neoplasm of prostate
• Z15.04 Genetic susceptibility to malignant neoplasm of endometrium
• Z15.05 Genetic susceptibility to malignant neoplasm of fallopian tube(s)
• Z15.06 Genetic susceptibility to malignant neoplasm of digestive system