Z16.342 Resistance to multiple antimycobacterial drugs

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applies from Z16 Resistance to antimicrobial drugs

Excludes1 (never code together)

• Methicillin resistant Staphylococcus aureus infection (A49.02)
• Methicillin resistant Staphylococcus aureus pneumonia (J15.212)
• Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02)

Code first

• the infection

Notes

• The codes in this category are provided for use as additional codes to identify the resistance and non-responsiveness of a condition to antimicrobial drugs.

Applies from Z16.3 Resistance to other antimicrobial drugs

Excludes1 (never code together)

• resistance to antibiotics (Z16.1-, Z16.2-)

Applies from Z16.34 Resistance to antimycobacterial drug(s)

Applicable to

• Resistance to tuberculostatics

MS-DRG index

Defines the logic of DRG(s) 867-869 in MDC 18.

Approximate ICD-9-CM (GEMs)

• V09.71 Infection with microorganisms with resistance to multiple antimycobacterial agents

Medicare Code Edits (MCE v43.1 (April 2026))

• Unacceptable principal diagnosis: These codes describe a circumstance which influences care but is not a current illness or injury, or capture only an underlying condition, and are unacceptable as principal diagnosis.

Diagnosis Index entries for Z16.342

• Resistance, resistant (to) › organism (s) › to › drug › antimycobacterial (single) › multiple
• Resistance, resistant (to) › organism (s) › to › drug › multiple drugs (MDRO) › antimycobacterials
• Resistance, resistant (to) › organism (s) › to › drug › tuberculostatics (single) › multiple

Nearby codes

• Z16.31 Resistance to antiparasitic drug(s)
• Z16.32 Resistance to antifungal drug(s)
• Z16.33 Resistance to antiviral drug(s)
• Z16.34 Resistance to antimycobacterial drug(s)
• Z16.341 Resistance to single antimycobacterial drug
• Z16.342 Resistance to multiple antimycobacterial drugs (this code)
• Z16.35 Resistance to multiple antimicrobial drugs
• Z16.39 Resistance to other specified antimicrobial drug