Z29.81 Encounter for HIV pre-exposure prophylaxis

Billable ICD-10-CM code, FY2026. Exempt from present-on-admission (POA) reporting.

Code also

• , if applicable, risk factors for HIV, such as:
• contact with and (suspected) exposure to human immunodeficiency virus [HIV] (Z20.6)
• high risk sexual behavior (Z72.5-)

Applies from Z29 Encounter for other prophylactic measures

Excludes1 (never code together)

• desensitization to allergens (Z51.6)
• prophylactic surgery (Z40.-)

MS-DRG index

Defines the logic of DRG(s) 951 in MDC 23.

Medicare Code Edits (MCE v43.1 (April 2026))

• Unacceptable principal diagnosis: These codes describe a circumstance which influences care but is not a current illness or injury, or capture only an underlying condition, and are unacceptable as principal diagnosis.

Diagnosis Index entries for Z29.81

• Encounter (with health service) (for) › HIV › pre-exposure prophylaxis
• Encounter (with health service) (for) › HIV › PrEP
• Encounter (with health service) (for) › prophylactic measures › HIV pre-exposure

Nearby codes

• Z29.12 Encounter for prophylactic antivenin
• Z29.13 Encounter for prophylactic Rho(D) immune globulin
• Z29.14 Encounter for prophylactic rabies immune globin
• Z29.3 Encounter for prophylactic fluoride administration
• Z29.8 Encounter for other specified prophylactic measures
• Z29.81 Encounter for HIV pre-exposure prophylaxis (this code)
• Z29.89 Encounter for other specified prophylactic measures
• Z29.9 Encounter for prophylactic measures, unspecified