Z79.620 Long term (current) use of immunosuppressive biologic

Billable ICD-10-CM code, FY2026. Exempt from present-on-admission (POA) reporting.

Applicable to

• Long term (current) use of adalimumab
• Long term (current) use of etanercept
• Long term (current) use of infliximab
• Long term (current) use of monoclonal antibodies

Applies from Z79 Long term (current) drug therapy

Includes

• long term (current) drug use for prophylactic purposes

Excludes2 (not included here)

• drug abuse and dependence (F11-F19)
• drug use complicating pregnancy, childbirth, and the puerperium (O99.32-)

Code also

• any therapeutic drug level monitoring (Z51.81)

Applies from Z79.6 Long term (current) use of immunomodulators and immunosuppressants

Excludes2 (not included here)

• long term (current) use of steroids (Z79.5-)
• long term (current) use of agents affecting estrogen receptors and estrogen levels (Z79.81-)

MS-DRG index

Defines the logic of DRG(s) 949-950 in MDC 23.

Medicare Code Edits (MCE v43.1 (April 2026))

• Unacceptable principal diagnosis: These codes describe a circumstance which influences care but is not a current illness or injury, or capture only an underlying condition, and are unacceptable as principal diagnosis.

Code annotations containing back-references to Z79.620

Back-references to Z79

• Code Also: Z51.81 Encounter for therapeutic drug level monitoring ("any long-term (current) drug therapy (Z79.-)")
• Type 2 Excludes: Z92.2 Personal history of drug therapy ("long term (current) drug therapy (Z79.-)")

Diagnosis Index entries for Z79.620

• Long-term (current) (prophylactic) drug therapy (use of) › adalimumab
• Long-term (current) (prophylactic) drug therapy (use of) › etanercept
• Long-term (current) (prophylactic) drug therapy (use of) › immunosuppressive biologic
• Long-term (current) (prophylactic) drug therapy (use of) › infliximab
• Long-term (current) (prophylactic) drug therapy (use of) › monoclonal antibodies

Nearby codes

• Z79.52 Long term (current) use of systemic steroids
• Z79.6 Long term (current) use of immunomodulators and immunosuppressants
• Z79.60 Long term (current) use of unspecified immunomodulators and immunosuppressants
• Z79.61 Long term (current) use of immunomodulator
• Z79.62 Long term (current) use of immunosuppressant
• Z79.620 Long term (current) use of immunosuppressive biologic (this code)
• Z79.621 Long term (current) use of calcineurin inhibitor
• Z79.622 Long term (current) use of Janus kinase inhibitor
• Z79.623 Long term (current) use of mammalian target of rapamycin (mTOR) inhibitor
• Z79.624 Long term (current) use of inhibitors of nucleotide synthesis
• Z79.63 Long term (current) use of chemotherapeutic agent