Z81.4 Family history of other substance abuse and dependence

Billable ICD-10-CM code, FY2026. Exempt from present-on-admission (POA) reporting.

Applicable to

• Conditions classifiable to F55

MS-DRG index

Defines the logic of DRG(s) 951 in MDC 23.

Approximate ICD-9-CM (GEMs)

• V19.8 Family history of other condition (approximate)

Medicare Code Edits (MCE v43.1 (April 2026))

• Unacceptable principal diagnosis: These codes describe a circumstance which influences care but is not a current illness or injury, or capture only an underlying condition, and are unacceptable as principal diagnosis.

Code annotations containing back-references to Z81.4

Back-references to Z81

• Use Additional: Z15 Genetic susceptibility to disease ("code, if applicable, for any associated family history of the disease (Z80-Z84)")

Diagnosis Index entries for Z81.4

• History › family (of) › substance abuse NEC

Nearby codes

• Z81 Family history of mental and behavioral disorders
• Z81.0 Family history of intellectual disabilities
• Z81.1 Family history of alcohol abuse and dependence
• Z81.2 Family history of tobacco abuse and dependence
• Z81.3 Family history of other psychoactive substance abuse and dependence
• Z81.4 Family history of other substance abuse and dependence (this code)
• Z81.8 Family history of other mental and behavioral disorders