Z88.8 Allergy status to other drugs, medicaments and biological substances

Billable ICD-10-CM code, FY2026. Exempt from present-on-admission (POA) reporting.

Applies from Z88 Allergy status to drugs, medicaments and biological substances

Excludes2 (not included here)

• Allergy status, other than to drugs and biological substances (Z91.0-)

MS-DRG index

Defines the logic of DRG(s) 951 in MDC 23.

Approximate ICD-9-CM (GEMs)

• V14.8 Personal history of allergy to other specified medicinal agents

Medicare Code Edits (MCE v43.1 (April 2026))

• Unacceptable principal diagnosis: These codes describe a circumstance which influences care but is not a current illness or injury, or capture only an underlying condition, and are unacceptable as principal diagnosis.

Code annotations containing back-references to Z88.8

Back-references to Z88

• Code Also: Z87.892 Personal history of anaphylaxis ("allergy status to drugs, medicaments and biological substances (Z88.-)")
• Type 2 Excludes: Z91.0 Allergy status, other than to drugs and biological substances ("Allergy status to drugs, medicaments, and biological substances (Z88.-)")

Diagnosis Index entries for Z88.8

• History › personal (of) › allergy (to) › drugs, medicaments and biological substances › specified NEC
• History › personal (of) › allergy (to) › medicinal agents › specified NEC

Nearby codes

• Z88.3 Allergy status to other anti-infective agents
• Z88.4 Allergy status to anesthetic agent
• Z88.5 Allergy status to narcotic agent
• Z88.6 Allergy status to analgesic agent
• Z88.7 Allergy status to serum and vaccine
• Z88.8 Allergy status to other drugs, medicaments and biological substances (this code)
• Z88.9 Allergy status to unspecified drugs, medicaments and biological substances