Z92.22 Personal history of monoclonal drug therapy

Billable ICD-10-CM code, FY2026. Exempt from present-on-admission (POA) reporting.

Excludes2 (not included here)

• personal history of immune checkpoint inhibitor therapy (Z92.26)

Applies from Z92 Personal history of medical treatment

Excludes2 (not included here)

• postprocedural states (Z98.-)

Applies from Z92.2 Personal history of drug therapy

Excludes2 (not included here)

• long term (current) drug therapy (Z79.-)

MS-DRG index

Defines the logic of DRG(s) 949-950 in MDC 23.

Approximate ICD-9-CM (GEMs)

• V87.42 Personal history of monoclonal drug therapy

Medicare Code Edits (MCE v43.1 (April 2026))

• Unacceptable principal diagnosis: These codes describe a circumstance which influences care but is not a current illness or injury, or capture only an underlying condition, and are unacceptable as principal diagnosis.

Code annotations containing back-references to Z92.22

Back-references to Z92

• Type 2 Excludes: Z87.7 Personal history of (corrected) congenital malformations ("personal history of medical treatment (Z92.-)")

Diagnosis Index entries for Z92.22

• History › personal (of) › drug therapy › monoclonal drug

Nearby codes

• Z92 Personal history of medical treatment
• Z92.0 Personal history of contraception
• Z92.2 Personal history of drug therapy
• Z92.21 Personal history of antineoplastic chemotherapy
• Z92.22 Personal history of monoclonal drug therapy (this code)
• Z92.23 Personal history of estrogen therapy
• Z92.24 Personal history of steroid therapy
• Z92.240 Personal history of inhaled steroid therapy
• Z92.241 Personal history of systemic steroid therapy
• Z92.25 Personal history of immunosuppression therapy