Z99.81 Dependence on supplemental oxygen

Billable ICD-10-CM code, FY2026. Exempt from present-on-admission (POA) reporting.

Applicable to

• Dependence on long-term oxygen

MS-DRG index

Defines the logic of DRG(s) 951 in MDC 23.

Approximate ICD-9-CM (GEMs)

• V46.2 Other dependence on machines, supplemental oxygen

Medicare Code Edits (MCE v43.1 (April 2026))

• Unacceptable principal diagnosis: These codes describe a circumstance which influences care but is not a current illness or injury, or capture only an underlying condition, and are unacceptable as principal diagnosis.

Code annotations containing back-references to Z99.81

Back-references to Z99

• Type 2 Excludes: Z74 Problems related to care provider dependency ("dependence on enabling machines or devices NEC (Z99.-)")
• Type 2 Excludes: Z78 Other specified health status ("postprocedural status (Z93-Z99)")

Diagnosis Index entries for Z99.81

• Dependence (on) (syndrome) › oxygen (long-term) (supplemental)
• Dependence (on) (syndrome) › supplemental oxygen

Nearby codes

• Z99.11 Dependence on respirator [ventilator] status
• Z99.12 Encounter for respirator [ventilator] dependence during power failure
• Z99.2 Dependence on renal dialysis
• Z99.3 Dependence on wheelchair
• Z99.8 Dependence on other enabling machines and devices
• Z99.81 Dependence on supplemental oxygen (this code)
• Z99.89 Dependence on other enabling machines and devices