A41.4 Sepsis due to anaerobes

Billable ICD-10-CM code, FY2026. Acts as a Major Complication or Comorbidity (MCC) as a secondary diagnosis.

Excludes1 (never code together)

• gas gangrene (A48.0)

Applies from A41 Other sepsis

Excludes1 (never code together)

• bacteremia NOS (R78.81)
• neonatal (P36.-)
• puerperal sepsis (O85)
• streptococcal sepsis (A40.-)

Excludes2 (not included here)

• sepsis (due to) (in) actinomycotic (A42.7)
• sepsis (due to) (in) anthrax (A22.7)
• sepsis (due to) (in) candidal (B37.7)
• sepsis (due to) (in) Erysipelothrix (A26.7)
• sepsis (due to) (in) extraintestinal yersiniosis (A28.2)
• sepsis (due to) (in) gonococcal (A54.86)
• sepsis (due to) (in) herpesviral (B00.7)
• sepsis (due to) (in) listerial (A32.7)
• sepsis (due to) (in) melioidosis (A24.1)
• sepsis (due to) (in) meningococcal (A39.2-A39.4)
• sepsis (due to) (in) plague (A20.7)
• sepsis (due to) (in) tularemia (A21.7)
• toxic shock syndrome (A48.3)

Code first

• , if applicable, postprocedural sepsis (T81.44-)
• sepsis due to central venous catheter (T80.211-)
• sepsis during labor (O75.3)
• sepsis following abortion, ectopic or molar pregnancy (O03.37, O03.87, O04.87, O07.37, O08.82)
• sepsis following immunization (T88.0-)
• sepsis following infusion, transfusion or therapeutic injection (T80.22-, T80.29-)

Risk adjustment (HCC)

• CMS-HCC V28: HCC 2 — Septicemia, Sepsis, Systemic Inflammatory Response Syndrome/Shock
• CMS-HCC V22: HCC 2 — Septicemia, Sepsis, Systemic Inflammatory Response Syndrome/Shock
• ESRD V24: HCC 2

MS-DRG index

Defines the logic of DRG(s) 791 in MDC 15.

Approximate ICD-9-CM (GEMs)

• 038.3 Septicemia due to anaerobes (approximate)
• 995.91 Sepsis (approximate)

Code annotations containing back-references to A41.4

Back-references to A41.4

• Code First: N08 Glomerular disorders in diseases classified elsewhere ("sepsis (A40.0-A41.9)")
• Code First: N16 Renal tubulo-interstitial disorders in diseases classified elsewhere ("sepsis (A40.0-A41.9)")

Back-references to A41

• Code First: I5A Non-ischemic myocardial injury (non-traumatic) ("sepsis (A41.-)")
• Use Additional: J95.02 Infection of tracheostomy stoma ("sepsis (A40, A41.-)")
• Use Additional: K94.02 Colostomy infection ("sepsis (A40.-, A41.-)")
• Use Additional: K94.12 Enterostomy infection ("sepsis (A40.-, A41.-)")
• Use Additional: K94.22 Gastrostomy infection ("sepsis (A40.-, A41.-)")
• Use Additional: K95.01 Infection due to gastric band procedure ("sepsis (A40.-, A41.-)")
• Use Additional: K95.81 Infection due to other bariatric procedure ("sepsis (A40.-, A41.-)")

Diagnosis Index entries for A41.4

• Infection, infected, infective (opportunistic) › Clostridioides › difficile › sepsis
• Infection, infected, infective (opportunistic) › Clostridium NEC › difficile › sepsis
• Infection, infected, infective (opportunistic) › Clostridium NEC › perfringens › sepsis
• Infection, infected, infective (opportunistic) › Clostridium NEC › welchii › sepsis
• Sepsis (generalized) (unspecified organism) › anaerobic
• Sepsis (generalized) (unspecified organism) › Gram-negative (organism) › anaerobic

Nearby codes

• A41.01 Sepsis due to Methicillin susceptible Staphylococcus aureus
• A41.02 Sepsis due to Methicillin resistant Staphylococcus aureus
• A41.1 Sepsis due to other specified staphylococcus
• A41.2 Sepsis due to unspecified staphylococcus
• A41.3 Sepsis due to Hemophilus influenzae
• A41.4 Sepsis due to anaerobes (this code)
• A41.5 Sepsis due to other Gram-negative organisms
• A41.50 Gram-negative sepsis, unspecified
• A41.51 Sepsis due to Escherichia coli [E. coli]
• A41.52 Sepsis due to Pseudomonas
• A41.53 Sepsis due to Serratia