N16 Renal tubulo-interstitial disorders in diseases classified elsewhere

Billable ICD-10-CM code, FY2026.

Applicable to

• Pyelonephritis
• Tubulo-interstitial nephritis

Excludes1 (never code together)

• diphtheritic pyelonephritis and tubulo-interstitial nephritis (A36.84)
• pyelonephritis and tubulo-interstitial nephritis in candidiasis (B37.49)
• pyelonephritis and tubulo-interstitial nephritis in cystinosis (E72.04)
• pyelonephritis and tubulo-interstitial nephritis in salmonella infection (A02.25)
• pyelonephritis and tubulo-interstitial nephritis in sarcoidosis (D86.84)
• pyelonephritis and tubulo-interstitial nephritis in Sjogren syndrome (M35.04)
• pyelonephritis and tubulo-interstitial nephritis in systemic lupus erythematosus (M32.15)
• pyelonephritis and tubulo-interstitial nephritis in toxoplasmosis (B58.83)
• renal tubular degeneration in diabetes (E08-E13 with .29)
• syphilitic pyelonephritis and tubulo-interstitial nephritis (A52.75)

Code first

• underlying disease, such as:
• brucellosis (A23.0-A23.9)
• cryoglobulinemia (D89.1)
• glycogen storage disease (E74.0-)
• leukemia (C91-C95)
• lymphoma (C81.0-C85.9, C96.0-C96.9)
• multiple myeloma (C90.0-)
• sepsis (A40.0-A41.9)
• Wilson's disease (E83.01)

Applies from N16 Renal tubulo-interstitial disorders in diseases classified elsewhere

Applicable to

• Pyelonephritis
• Tubulo-interstitial nephritis

Excludes1 (never code together)

• diphtheritic pyelonephritis and tubulo-interstitial nephritis (A36.84)
• pyelonephritis and tubulo-interstitial nephritis in candidiasis (B37.49)
• pyelonephritis and tubulo-interstitial nephritis in cystinosis (E72.04)
• pyelonephritis and tubulo-interstitial nephritis in salmonella infection (A02.25)
• pyelonephritis and tubulo-interstitial nephritis in sarcoidosis (D86.84)
• pyelonephritis and tubulo-interstitial nephritis in Sjogren syndrome (M35.04)
• pyelonephritis and tubulo-interstitial nephritis in systemic lupus erythematosus (M32.15)
• pyelonephritis and tubulo-interstitial nephritis in toxoplasmosis (B58.83)
• renal tubular degeneration in diabetes (E08-E13 with .29)
• syphilitic pyelonephritis and tubulo-interstitial nephritis (A52.75)

Code first

• underlying disease, such as:
• brucellosis (A23.0-A23.9)
• cryoglobulinemia (D89.1)
• glycogen storage disease (E74.0-)
• leukemia (C91-C95)
• lymphoma (C81.0-C85.9, C96.0-C96.9)
• multiple myeloma (C90.0-)
• sepsis (A40.0-A41.9)
• Wilson's disease (E83.01)

MS-DRG index

Defines the logic of DRG(s) 698-700 in MDC 11.

Approximate ICD-9-CM (GEMs)

• 583.81 Nephritis and nephropathy, not specified as acute or chronic, in diseases classified elsewhere (approximate)
• 590.81 Pyelitis or pyelonephritis in diseases classified elsewhere (approximate)

Medicare Code Edits (MCE v43.1 (April 2026))

• Manifestation codes as principal diagnosis: Manifestation codes describe the manifestation of an underlying disease, not the disease itself, and are not allowed as principal diagnosis.

Code annotations containing back-references to N16

Back-references to N16

• Type 1 Excludes: N08 Glomerular disorders in diseases classified elsewhere ("pyelonephritis in diseases classified elsewhere (N16)")
• Type 1 Excludes: N08 Glomerular disorders in diseases classified elsewhere ("renal tubulo-interstitial disorders classified elsewhere (N16)")

Back-references to N16

• Type 1 Excludes: N08 Glomerular disorders in diseases classified elsewhere ("pyelonephritis in diseases classified elsewhere (N16)")
• Type 1 Excludes: N08 Glomerular disorders in diseases classified elsewhere ("renal tubulo-interstitial disorders classified elsewhere (N16)")

Diagnosis Index entries for N16

• Disorder (of) › tubulo-interstitial (in) › brucellosis
• Disorder (of) › tubulo-interstitial (in) › glycogen storage disease
• Disorder (of) › tubulo-interstitial (in) › leukemia NEC
• Disorder (of) › tubulo-interstitial (in) › lymphoma NEC
• Disorder (of) › tubulo-interstitial (in) › mixed cryoglobulinemia
• Disorder (of) › tubulo-interstitial (in) › multiple myeloma
• Disorder (of) › tubulo-interstitial (in) › sepsis
• Disorder (of) › tubulo-interstitial (in) › sepsis › streptococcal
• Disorder (of) › tubulo-interstitial (in) › transplant rejection
• Disorder (of) › tubulo-interstitial (in) › Wilson's disease
• Nephritis, nephritic (albuminuric) (azotemic) (congenital) (disseminated) (epithelial) (familial) (focal) (granulomatous) (hemorrhagic) (infantile) (nonsuppurative, excretory) (uremic) › tubulo-interstitial (in) › due to › brucellosis
• Nephritis, nephritic (albuminuric) (azotemic) (congenital) (disseminated) (epithelial) (familial) (focal) (granulomatous) (hemorrhagic) (infantile) (nonsuppurative, excretory) (uremic) › tubulo-interstitial (in) › due to › cryoglobulinemia
• Nephritis, nephritic (albuminuric) (azotemic) (congenital) (disseminated) (epithelial) (familial) (focal) (granulomatous) (hemorrhagic) (infantile) (nonsuppurative, excretory) (uremic) › tubulo-interstitial (in) › due to › glycogen storage disease
• Pyelonephritis › in (due to) › brucellosis
• Pyelonephritis › in (due to) › cryoglobulinemia (mixed)
• Pyelonephritis › in (due to) › glycogen storage disease
• Pyelonephritis › in (due to) › leukemia NEC
• Pyelonephritis › in (due to) › lymphoma NEC
• Pyelonephritis › in (due to) › multiple myeloma
• Pyelonephritis › in (due to) › sepsis
• Pyelonephritis › in (due to) › transplant rejection
• Pyelonephritis › in (due to) › Wilson's disease

Nearby codes

• N16 Renal tubulo-interstitial disorders in diseases classified elsewhere (this code)