C22.0 Liver cell carcinoma

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applicable to

• Hepatocellular carcinoma
• Hepatoma

Applies from C22 Malignant neoplasm of liver and intrahepatic bile ducts

Excludes1 (never code together)

• malignant neoplasm of biliary tract NOS (C24.9)
• secondary malignant neoplasm of liver and intrahepatic bile duct (C78.7)

Use additional code

• code to identify:
• alcohol abuse and dependence (F10.-)
• hepatitis B (B16.-, B18.0-B18.1)
• hepatitis C (B17.1-, B18.2)

Risk adjustment (HCC)

• CMS-HCC V28: HCC 20 — Lung and Other Severe Cancers
• CMS-HCC V22: HCC 9 — Lung and Other Severe Cancers
• RxHCC V08: HCC 20 — Lung, Kidney, and Other Cancers; Secondary Cancer of Lymph Nodes and Other Sites
• ESRD V24: HCC 9

MS-DRG index

Defines the logic of DRG(s) 435-437 in MDC 07.

Approximate ICD-9-CM (GEMs)

• 155.0 Malignant neoplasm of liver, primary (approximate)

Diagnosis Index entries for C22.0

• Cancer › hepatocellular
• Carcinoma (malignant) › bile duct › with hepatocellular, mixed
• Carcinoma (malignant) › hepatic cell
• Carcinoma (malignant) › hepatocellular
• Carcinoma (malignant) › hepatocellular › with bile duct, mixed
• Carcinoma (malignant) › hepatocellular › fibrolamellar
• Carcinoma (malignant) › hepatocholangiolitic
• Carcinoma (malignant) › liver cell
• Cholangiocarcinoma › with hepatocellular carcinoma, combined
• Cholangiohepatoma
• Embryoma › liver
• Embryoma › malignant › liver
• Hepatocarcinoma
• Hepatocholangiocarcinoma
• Hepatoma (malignant)
• Hepatoma (malignant) › embryonal

Nearby codes

• C22 Malignant neoplasm of liver and intrahepatic bile ducts
• C22.0 Liver cell carcinoma (this code)
• C22.1 Intrahepatic bile duct carcinoma
• C22.2 Hepatoblastoma
• C22.3 Angiosarcoma of liver
• C22.4 Other sarcomas of liver
• C22.7 Other specified carcinomas of liver