C85.27 Mediastinal (thymic) large B-cell lymphoma, spleen

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applies from C85 Other specified and unspecified types of non-Hodgkin lymphoma

Excludes1 (never code together)

• other specified types of T/NK-cell lymphoma (C86.-)
• personal history of non-Hodgkin lymphoma (Z85.72)

Risk adjustment (HCC)

• CMS-HCC V28: HCC 21 — Lymphoma and Other Cancers
• CMS-HCC V22: HCC 10 — Lymphoma and Other Cancers
• RxHCC V08: HCC 21 — Lymphomas and Other Hematologic Cancers
• ESRD V24: HCC 10

MS-DRG index

Defines the logic of DRG(s) 820-822 in MDC 17.

Approximate ICD-9-CM (GEMs)

• 200.77 Large cell lymphoma, spleen (approximate)
• 202.87 Other malignant lymphomas, spleen (approximate)

Code annotations containing back-references to C85.27

Back-references to C85.2

• Type 1 Excludes: C83.3 Diffuse large B-cell lymphoma ("mediastinal (thymic) large B-cell lymphoma (C85.2-)")
• Type 1 Excludes: C83.8 Other non-follicular lymphoma ("mediastinal (thymic) large B-cell lymphoma (C85.2-)")

Back-references to C85

• Type 1 Excludes: C26.1 Malignant neoplasm of spleen ("non-Hodgkin lymphoma (C82-C85)")
• Type 1 Excludes: C76 Malignant neoplasm of other and ill-defined sites ("malignant neoplasm of lymphoid, hematopoietic and related tissue (C81-C96)")
• Type 1 Excludes: C77 Secondary and unspecified malignant neoplasm of lymph nodes ("malignant neoplasm of lymph nodes, specified as primary (C81-C86, C88, C96.-)")
• Code Also: D47.02 Systemic mastocytosis ("non-Hodgkin lymphoma (C82-C85)")
• Code First: Z15.0 Genetic susceptibility to malignant neoplasm (", if applicable, any current malignant neoplasm (C00-C75, C81-C96)")

Nearby codes

• C85.22 Mediastinal (thymic) large B-cell lymphoma, intrathoracic lymph nodes
• C85.23 Mediastinal (thymic) large B-cell lymphoma, intra-abdominal lymph nodes
• C85.24 Mediastinal (thymic) large B-cell lymphoma, lymph nodes of axilla and upper limb
• C85.25 Mediastinal (thymic) large B-cell lymphoma, lymph nodes of inguinal region and lower limb
• C85.26 Mediastinal (thymic) large B-cell lymphoma, intrapelvic lymph nodes
• C85.27 Mediastinal (thymic) large B-cell lymphoma, spleen (this code)
• C85.28 Mediastinal (thymic) large B-cell lymphoma, lymph nodes of multiple sites
• C85.29 Mediastinal (thymic) large B-cell lymphoma, extranodal and solid organ sites
• C85.2A Mediastinal (thymic) large B-cell lymphoma, in remission
• C85.8 Other specified types of non-Hodgkin lymphoma
• C85.80 Other specified types of non-Hodgkin lymphoma, unspecified site