C90.12 Plasma cell leukemia in relapse

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applies from C90 Multiple myeloma and malignant plasma cell neoplasms

Excludes1 (never code together)

• personal history of other malignant neoplasms of lymphoid, hematopoietic and related tissues (Z85.79)

Applies from C90.1 Plasma cell leukemia

Applicable to

• Plasmacytic leukemia

Risk adjustment (HCC)

• CMS-HCC V28: HCC 19 — Myelodysplastic Syndromes, Multiple Myeloma, and Other Cancers
• CMS-HCC V22: HCC 9 — Lung and Other Severe Cancers
• RxHCC V08: HCC 16 — Multiple Myeloma and Other Hematologic Cancers
• ESRD V24: HCC 9

MS-DRG index

Defines the logic of DRG(s) 820-822 in MDC 17.

Approximate ICD-9-CM (GEMs)

• 203.12 Plasma cell leukemia, in relapse

Code annotations containing back-references to C90.12

Back-references to C90.1

• Type 1 Excludes: C94 Other leukemias of specified cell type ("plasma cell leukemia (C90.1-)")

Back-references to C90

• Type 1 Excludes: C76 Malignant neoplasm of other and ill-defined sites ("malignant neoplasm of lymphoid, hematopoietic and related tissue (C81-C96)")
• Code First: Z15.0 Genetic susceptibility to malignant neoplasm (", if applicable, any current malignant neoplasm (C00-C75, C81-C96)")

Nearby codes

• C90.01 Multiple myeloma in remission
• C90.02 Multiple myeloma in relapse
• C90.1 Plasma cell leukemia
• C90.10 Plasma cell leukemia not having achieved remission
• C90.11 Plasma cell leukemia in remission
• C90.12 Plasma cell leukemia in relapse (this code)
• C90.2 Extramedullary plasmacytoma
• C90.20 Extramedullary plasmacytoma not having achieved remission
• C90.21 Extramedullary plasmacytoma in remission
• C90.22 Extramedullary plasmacytoma in relapse
• C90.3 Solitary plasmacytoma