C90.22 Extramedullary plasmacytoma in relapse

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applies from C90 Multiple myeloma and malignant plasma cell neoplasms

Excludes1 (never code together)

• personal history of other malignant neoplasms of lymphoid, hematopoietic and related tissues (Z85.79)

Risk adjustment (HCC)

• CMS-HCC V28: HCC 19 — Myelodysplastic Syndromes, Multiple Myeloma, and Other Cancers
• CMS-HCC V22: HCC 9 — Lung and Other Severe Cancers
• RxHCC V08: HCC 16 — Multiple Myeloma and Other Hematologic Cancers
• ESRD V24: HCC 9

MS-DRG index

Defines the logic of DRG(s) 820-822 in MDC 17.

Approximate ICD-9-CM (GEMs)

• 203.82 Other immunoproliferative neoplasms, in relapse (approximate)

Code annotations containing back-references to C90.22

Back-references to C90

• Type 1 Excludes: C76 Malignant neoplasm of other and ill-defined sites ("malignant neoplasm of lymphoid, hematopoietic and related tissue (C81-C96)")
• Code First: Z15.0 Genetic susceptibility to malignant neoplasm (", if applicable, any current malignant neoplasm (C00-C75, C81-C96)")

Nearby codes

• C90.11 Plasma cell leukemia in remission
• C90.12 Plasma cell leukemia in relapse
• C90.2 Extramedullary plasmacytoma
• C90.20 Extramedullary plasmacytoma not having achieved remission
• C90.21 Extramedullary plasmacytoma in remission
• C90.22 Extramedullary plasmacytoma in relapse (this code)
• C90.3 Solitary plasmacytoma
• C90.30 Solitary plasmacytoma not having achieved remission
• C90.31 Solitary plasmacytoma in remission
• C90.32 Solitary plasmacytoma in relapse