D53.0 Protein deficiency anemia

Billable ICD-10-CM code, FY2026.

Applicable to

• Amino-acid deficiency anemia
• Orotaciduric anemia

Excludes1 (never code together)

• Lesch-Nyhan syndrome (E79.1)

Applies from D53 Other nutritional anemias

Includes

• megaloblastic anemia unresponsive to vitamin B12 or folate therapy

MS-DRG index

Defines the logic of DRG(s) 811-812 in MDC 16.

Approximate ICD-9-CM (GEMs)

• 281.4 Protein-deficiency anemia

Code annotations containing back-references to D53.0

Back-references to D53.0

• Type 1 Excludes: E79 Disorders of purine and pyrimidine metabolism ("orotaciduric anemia (D53.0)")

Back-references to D53

• Code First: M90.5 Osteonecrosis in diseases classified elsewhere ("hemoglobinopathy (D50-D64)")
• Type 1 Excludes: R71 Abnormality of red blood cells ("anemias (D50-D64)")

Diagnosis Index entries for D53.0

• Aciduria › orotic (congenital) (hereditary) (pyrimidine deficiency) › anemia
• Amino-acid disorder › anemia
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › amino-acid-deficiency
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › amino-acid
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › protein
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › due to (in) (with) › deficiency › amino-acid
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › due to (in) (with) › deficiency › protein
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › megaloblastic › orotic aciduria
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › orotaciduric (congenital) (hereditary)
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › protein-deficiency
• Deficiency, deficient › protein › anemia
• Orotaciduria, oroticaciduria (congenital) (hereditary) (pyrimidine deficiency) › anemia

Nearby codes

• D53 Other nutritional anemias
• D53.0 Protein deficiency anemia (this code)
• D53.1 Other megaloblastic anemias, not elsewhere classified
• D53.2 Scorbutic anemia
• D53.8 Other specified nutritional anemias
• D53.9 Nutritional anemia, unspecified