D57.00 Hb-SS disease with crisis, unspecified

Billable ICD-10-CM code, FY2026. Acts as a Major Complication or Comorbidity (MCC) as a secondary diagnosis.

Applicable to

• Hb-SS disease with (painful) crisis NOS
• Hb-SS disease with (vaso-occlusive) pain NOS

Applies from D57 Sickle-cell disorders

Excludes1 (never code together)

• other hemoglobinopathies (D58.-)

Use additional code

• code for any associated fever (R50.81)

Applies from D57.0 Hb-SS disease with crisis

Applicable to

• Sickle-cell disease with crisis
• Hb-SS disease with (vaso-occlusive) pain

Risk adjustment (HCC)

• CMS-HCC V28: HCC 107 — Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero
• CMS-HCC V22: HCC 46 — Severe Hematological Disorders
• RxHCC V08: HCC 95 — Sickle Cell Anemia
• ESRD V24: HCC 46

MS-DRG index

Defines the logic of DRG(s) 811-812 in MDC 16.

Approximate ICD-9-CM (GEMs)

• 282.62 Hb-SS disease with crisis (approximate)

Code annotations containing back-references to D57.00

Back-references to D57.0

• Code First: N08 Glomerular disorders in diseases classified elsewhere ("sickle-cell disease (D57.0-D57.8)")

Back-references to D57

• Type 1 Excludes: D56.8 Other thalassemias ("sickle-cell anemia (D57.-)")
• Code First: H36 Retinal disorders in diseases classified elsewhere ("sickle-cell disorders (D57.-)")
• Code First: M14.8 Arthropathies in other specified diseases classified elsewhere ("sickle-cell disorders (D57.-)")
• Code First: M90.5 Osteonecrosis in diseases classified elsewhere ("hemoglobinopathy (D50-D64)")
• Code First: R50.81 Fever presenting with conditions classified elsewhere ("sickle-cell disease (D57.-)")
• Type 1 Excludes: R71 Abnormality of red blood cells ("anemias (D50-D64)")
• Code Also: Z71.87 Encounter for pediatric-to-adult transition counseling ("sickle-cell disorder (D57.-)")

Diagnosis Index entries for D57.00

• Crisis › sickle-cell
• Crisis › sickle-cell › with › pain (vaso-occlusive)
• Disease, diseased › hemoglobin or Hb › S or SS › with › crisis (painful)
• Disease, diseased › hemoglobin or Hb › S or SS › with › pain (vaso-occlusive)
• Disease, diseased › sickle-cell › with › crisis (painful)
• Disease, diseased › sickle-cell › with › pain (vaso-occlusive)

Nearby codes

• D57 Sickle-cell disorders
• D57.0 Hb-SS disease with crisis
• D57.00 Hb-SS disease with crisis, unspecified (this code)
• D57.01 Hb-SS disease with acute chest syndrome
• D57.02 Hb-SS disease with splenic sequestration
• D57.03 Hb-SS disease with cerebral vascular involvement
• D57.04 Hb-SS disease with dactylitis
• D57.09 Hb-SS disease with crisis with other specified complication