D59.2 Drug-induced nonautoimmune hemolytic anemia

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applicable to

• Drug-induced enzyme deficiency anemia

Use additional code

• code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Risk adjustment (HCC)

• CMS-HCC V22: HCC 46 — Severe Hematological Disorders
• RxHCC V08: HCC 96 — Acquired Hemolytic, Aplastic, and Sideroblastic Anemias
• ESRD V24: HCC 46

MS-DRG index

Defines the logic of DRG(s) 791 in MDC 15.

Approximate ICD-9-CM (GEMs)

• 283.19 Other non-autoimmune hemolytic anemias (approximate)

Code annotations containing back-references to D59.2

Back-references to D59.2

• Type 1 Excludes: D55 Anemia due to enzyme disorders ("drug-induced enzyme deficiency anemia (D59.2)")

Back-references to D59

• Code First: M90.5 Osteonecrosis in diseases classified elsewhere ("hemoglobinopathy (D50-D64)")
• Type 1 Excludes: R71 Abnormality of red blood cells ("anemias (D50-D64)")

Diagnosis Index entries for D59.2

• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › enzyme › drug-induced (hemolytic)
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › enzyme-deficiency, drug-induced
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › hemolytic › due to › drugs (nonautoimmune)
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › hemolytic › due to › enzyme disorder › drug-induced
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › hemolytic › nonautoimmune › drug-induced
• Disease, diseased › nonautoimmune hemolytic › drug-induced
• Nonautoimmune hemolytic anemia › drug-induced

Nearby codes

• D59.10 Autoimmune hemolytic anemia, unspecified
• D59.11 Warm autoimmune hemolytic anemia
• D59.12 Cold autoimmune hemolytic anemia
• D59.13 Mixed type autoimmune hemolytic anemia
• D59.19 Other autoimmune hemolytic anemia
• D59.2 Drug-induced nonautoimmune hemolytic anemia (this code)
• D59.3 Hemolytic-uremic syndrome
• D59.30 Hemolytic-uremic syndrome, unspecified
• D59.31 Infection-associated hemolytic-uremic syndrome
• D59.32 Hereditary hemolytic-uremic syndrome
• D59.39 Other hemolytic-uremic syndrome