D59.31 Infection-associated hemolytic-uremic syndrome

Billable ICD-10-CM code, FY2026. Acts as a Major Complication or Comorbidity (MCC) as a secondary diagnosis.

Applicable to

• Shiga toxin-producing E. coli [STEC] related hemolytic uremic syndrome
• Typical hemolytic uremic syndrome

Use additional code

• code to identify associated infection, such as :
• E. coli infection (B96.2-)
• Human immunodeficiency virus [HIV] disease (B20)
• Pneumococcal meningitis (G00.1)
• Pneumococcal pneumonia (J13)
• Sepsis due to Streptococcus pneumoniae (A40.3)
• Shigella dysenteriae (A03.9)
• Streptococcus pneumoniae as the cause of diseases classified elsewhere (B95.3)

Applies from D59.3 Hemolytic-uremic syndrome

Code also

• , if applicable, any associated:
• acute kidney failure (N17.-)
• chronic kidney disease (N18.-)

Risk adjustment (HCC)

• CMS-HCC V28: HCC 109 — Acquired Hemolytic, Aplastic, and Sideroblastic Anemias
• CMS-HCC V22: HCC 46 — Severe Hematological Disorders
• RxHCC V08: HCC 96 — Acquired Hemolytic, Aplastic, and Sideroblastic Anemias
• ESRD V24: HCC 46

MS-DRG index

Defines the logic of DRG(s) 791 in MDC 15.

Code annotations containing back-references to D59.31

Back-references to D59.3

• Type 1 Excludes: D69.1 Qualitative platelet defects ("hemolytic-uremic syndrome (D59.3-)")
• Use Additional: M31.11 Hematopoietic stem cell transplantation-associated thrombotic microangiopathy [HSCT-TMA] ("hemolytic uremic syndrome (D59.3-)")
• Type 1 Excludes: N08 Glomerular disorders in diseases classified elsewhere ("hemolytic-uremic syndrome (D59.3-)")

Back-references to D59

• Code First: M90.5 Osteonecrosis in diseases classified elsewhere ("hemoglobinopathy (D50-D64)")
• Type 1 Excludes: R71 Abnormality of red blood cells ("anemias (D50-D64)")

Diagnosis Index entries for D59.31

• Syndrome › hemolytic-uremic › atypical › infection-associated
• Syndrome › hemolytic-uremic › infection-associated
• Syndrome › hemolytic-uremic › Shiga toxin-producing E. coli [STEC] related
• Syndrome › hemolytic-uremic › typical

Nearby codes

• D59.13 Mixed type autoimmune hemolytic anemia
• D59.19 Other autoimmune hemolytic anemia
• D59.2 Drug-induced nonautoimmune hemolytic anemia
• D59.3 Hemolytic-uremic syndrome
• D59.30 Hemolytic-uremic syndrome, unspecified
• D59.31 Infection-associated hemolytic-uremic syndrome (this code)
• D59.32 Hereditary hemolytic-uremic syndrome
• D59.39 Other hemolytic-uremic syndrome
• D59.4 Other nonautoimmune hemolytic anemias
• D59.5 Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
• D59.6 Hemoglobinuria due to hemolysis from other external causes