D59.5 Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]

Billable ICD-10-CM code, FY2026.

Excludes1 (never code together)

• hemoglobinuria NOS (R82.3)

Risk adjustment (HCC)

• CMS-HCC V28: HCC 109 — Acquired Hemolytic, Aplastic, and Sideroblastic Anemias
• CMS-HCC V22: HCC 46 — Severe Hematological Disorders
• RxHCC V08: HCC 96 — Acquired Hemolytic, Aplastic, and Sideroblastic Anemias
• ESRD V24: HCC 46

MS-DRG index

Defines the logic of DRG(s) 791 in MDC 15.

Approximate ICD-9-CM (GEMs)

• 283.2 Hemoglobinuria due to hemolysis from external causes (approximate)

Code annotations containing back-references to D59.5

Back-references to D59.5

• Type 1 Excludes: R82.3 Hemoglobinuria ("hemoglobinuria due to paroxysmal nocturnal [Marchiafava-Micheli] (D59.5)")

Back-references to D59

• Code First: M90.5 Osteonecrosis in diseases classified elsewhere ("hemoglobinopathy (D50-D64)")
• Type 1 Excludes: R71 Abnormality of red blood cells ("anemias (D50-D64)")

Diagnosis Index entries for D59.5

• Hematuria › paroxysmal › nocturnal
• Hemoglobinemia › paroxysmal › nocturnal
• Hemoglobinuria › nocturnal (paroxysmal)
• Hemoglobinuria › paroxysmal (cold) › nocturnal
• Marchiafava-Micheli syndrome

Nearby codes

• D59.30 Hemolytic-uremic syndrome, unspecified
• D59.31 Infection-associated hemolytic-uremic syndrome
• D59.32 Hereditary hemolytic-uremic syndrome
• D59.39 Other hemolytic-uremic syndrome
• D59.4 Other nonautoimmune hemolytic anemias
• D59.5 Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli] (this code)
• D59.6 Hemoglobinuria due to hemolysis from other external causes
• D59.8 Other acquired hemolytic anemias
• D59.9 Acquired hemolytic anemia, unspecified