M31.11 Hematopoietic stem cell transplantation-associated thrombotic microangiopathy [HSCT-TMA]

Billable ICD-10-CM code, FY2026. Acts as a Major Complication or Comorbidity (MCC) as a secondary diagnosis.

Applicable to

• Transplant-associated thrombotic microangiopathy [TA-TMA]

Code first

• if applicable:
• complications of bone marrow transplant (T86.0-)
• complications of stem cell transplant (T86.5)

Use additional code

• code to identify specific organ dysfunction, such as:
• acute kidney failure (N17.-)
• acute respiratory distress syndrome (J80)
• capillary leak syndrome (I78.8)
• diffuse alveolar hemorrhage (R04.89)
• encephalopathy (metabolic) (septic) (G93.41)
• fluid overload, unspecified (E87.70)
• graft versus host disease (D89.81-)
• hemolytic uremic syndrome (D59.3-)
• hepatic failure (K72.-)
• hepatic veno-occlusive disease (K76.5)
• idiopathic interstitial pneumonia (J84.11-)
• sinusoidal obstruction syndrome (K76.5)

Risk adjustment (HCC)

• CMS-HCC V28: HCC 454 — Stem Cell, Including Bone Marrow, Transplant Status/Complications
• CMS-HCC V22: HCC 186 — Major Organ Transplant or Replacement Status
• RxHCC V08: HCC 395 — Stem Cell, Including Bone Marrow, Transplant Status/Complications
• ESRD V24: HCC 186

MS-DRG index

Defines the logic of DRG(s) 545-547 in MDC 08.

Code annotations containing back-references to M31.11

Back-references to M31

• Type 2 Excludes: I77 Other disorders of arteries and arterioles ("collagen (vascular) diseases (M30-M36)")
• Type 2 Excludes: J82 Pulmonary eosinophilia, not elsewhere classified ("pulmonary eosinophilia due to systemic connective tissue disorders (M30-M36)")
• Code First: J84.170 Interstitial lung disease with progressive fibrotic phenotype in diseases classified elsewhere ("systemic connective tissue disorders (M30-M36)")
• Type 1 Excludes: L94 Other localized connective tissue disorders ("systemic connective tissue disorders (M30-M36)")

Diagnosis Index entries for M31.11

• HSCT-TMA (hematopoietic stem cell transplantation-associated thrombotic microangiopathy)
• Microangiopathy (peripheral) › thrombotic › hematopoietic stem cell transplantation-associated [HSCT-TMA]

Nearby codes

• M31 Other necrotizing vasculopathies
• M31.0 Hypersensitivity angiitis
• M31.1 Thrombotic microangiopathy
• M31.10 Thrombotic microangiopathy, unspecified
• M31.11 Hematopoietic stem cell transplantation-associated thrombotic microangiopathy [HSCT-TMA] (this code)
• M31.19 Other thrombotic microangiopathy
• M31.2 Lethal midline granuloma
• M31.3 Wegener's granulomatosis
• M31.30 Wegener's granulomatosis without renal involvement
• M31.31 Wegener's granulomatosis with renal involvement