D72.12 Drug rash with eosinophilia and systemic symptoms syndrome

Billable ICD-10-CM code, FY2026.

Applicable to

• DRESS syndrome

Use additional code

• code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Applies from D72 Other disorders of white blood cells

Excludes1 (never code together)

• basophilia (D72.824)
• immunity disorders (D80-D89)
• neutropenia (D70)
• preleukemia (syndrome) (D46.9)

Applies from D72.1 Eosinophilia

Excludes2 (not included here)

• Löffler's syndrome (J82.89)
• pulmonary eosinophilia (J82.-)

MS-DRG index

Defines the logic of DRG(s) 814-816 in MDC 16.

Code annotations containing back-references to D72.12

Back-references to D72.1

• Code Also: D47.02 Systemic mastocytosis ("hypereosinophilic syndrome (D72.1)")
• Type 1 Excludes: D72.82 Elevated white blood cell count ("eosinophilia (D72.1)")

Diagnosis Index entries for D72.12

• Syndrome › DRESS (drug rash with eosinophilia and systemic symptoms)
• Syndrome › drug rash with eosinophilia and systemic symptoms (DRESS)

Nearby codes

• D72.11 Hypereosinophilic syndrome [HES]
• D72.110 Idiopathic hypereosinophilic syndrome [IHES]
• D72.111 Lymphocytic Variant Hypereosinophilic Syndrome [LHES]
• D72.118 Other hypereosinophilic syndrome
• D72.119 Hypereosinophilic syndrome [HES], unspecified
• D72.12 Drug rash with eosinophilia and systemic symptoms syndrome (this code)
• D72.18 Eosinophilia in diseases classified elsewhere
• D72.19 Other eosinophilia
• D72.8 Other specified disorders of white blood cells
• D72.81 Decreased white blood cell count
• D72.810 Lymphocytopenia