D76.2 Hemophagocytic syndrome, infection-associated

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Use additional code

• code to identify infectious agent or disease.

Applies from D76 Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue

Excludes1 (never code together)

• (Abt-) Letterer-Siwe disease (C96.0)
• eosinophilic granuloma (C96.6)
• Hand-Schüller-Christian disease (C96.5)
• histiocytic medullary reticulosis (C96.9)
• histiocytic sarcoma (C96.A)
• histiocytosis X, multifocal (C96.5)
• histiocytosis X, unifocal (C96.6)
• Langerhans-cell histiocytosis, multifocal (C96.5)
• Langerhans-cell histiocytosis NOS (C96.6)
• Langerhans-cell histiocytosis, unifocal (C96.6)
• leukemic reticuloendotheliosis (C91.4-)
• lipomelanotic reticulosis (I89.8)
• malignant histiocytosis (C96.A)
• malignant reticulosis (C86.0)
• nonlipid reticuloendotheliosis (C96.0)

Risk adjustment (HCC)

• CMS-HCC V22: HCC 47 — Disorders of Immunity
• ESRD V24: HCC 47

MS-DRG index

Defines the logic of DRG(s) 814-816 in MDC 16.

Approximate ICD-9-CM (GEMs)

• 288.4 Hemophagocytic syndromes (approximate)

Diagnosis Index entries for D76.2

• Syndrome › hemophagocytic, infection-associated
• Syndrome › macrophage activation › due to infection

Nearby codes

• D76 Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue
• D76.1 Hemophagocytic lymphohistiocytosis
• D76.2 Hemophagocytic syndrome, infection-associated (this code)
• D76.3 Other histiocytosis syndromes