E23.0 Hypopituitarism

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applicable to

• Fertile eunuch syndrome
• Hypogonadotropic hypogonadism
• Idiopathic growth hormone deficiency
• Isolated deficiency of gonadotropin
• Isolated deficiency of growth hormone
• Isolated deficiency of pituitary hormone
• Kallmann's syndrome
• Lorain-Levi short stature
• Necrosis of pituitary gland (postpartum)
• Panhypopituitarism
• Pituitary cachexia
• Pituitary insufficiency NOS
• Pituitary short stature
• Sheehan's syndrome
• Simmonds' disease

Use additional code

• code, if applicable, for associated cachexia (E88.A)

Applies from E23 Hypofunction and other disorders of the pituitary gland

Includes

• the listed conditions whether the disorder is in the pituitary or the hypothalamus

Excludes1 (never code together)

• postprocedural hypopituitarism (E89.3)
• short stature due to endocrine disorder (E34.3-)

Risk adjustment (HCC)

• CMS-HCC V22: HCC 23 — Other Significant Endocrine and Metabolic Disorders
• RxHCC V08: HCC 43 — Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders
• ESRD V24: HCC 23

MS-DRG index

Defines the logic of DRG(s) 643-645 in MDC 10.

Approximate ICD-9-CM (GEMs)

• 253.2 Panhypopituitarism (approximate)
• 253.3 Pituitary dwarfism (approximate)
• 628.1 Infertility, female, of pituitary-hypothalamic origin (approximate)

Code annotations containing back-references to E23.0

Back-references to E23.0

• Type 1 Excludes: E28 Ovarian dysfunction ("isolated gonadotropin deficiency (E23.0)")
• Type 1 Excludes: E29 Testicular dysfunction ("isolated gonadotropin deficiency (E23.0)")
• Type 1 Excludes: E34.3 Short stature due to endocrine disorder ("pituitary short stature (E23.0)")
• Type 2 Excludes: N97 Female infertility ("hypopituitarism (E23.0)")
• Type 1 Excludes: R62 Lack of expected normal physiological development in childhood and adults ("hypopituitarism (E23.0)")

Back-references to E23

• Code First: G63 Polyneuropathy in diseases classified elsewhere ("endocrine disease, except diabetes (E00-E07, E15-E16, E20-E34)")

Diagnosis Index entries for E23.0

• Ahumada-del Castillo syndrome
• Brissaud's › infantilism or dwarfism
• Cachexia › hypophyseal
• Cachexia › hypopituitary
• Cachexia › pituitary
• Cachexia › Simmonds'
• Decrease (d) › function › ovary in hypopituitarism
• Decrease (d) › function › pituitary (gland) (anterior) (lobe)
• Decrease (d) › function › pituitary (gland) (anterior) (lobe) › posterior (lobe)
• Deficiency, deficient › gonadotropin (isolated)
• Deficiency, deficient › growth hormone (idiopathic) (isolated)
• Deficiency, deficient › hormone › anterior pituitary (partial) NEC
• Deficiency, deficient › hormone › anterior pituitary (partial) NEC › growth
• Deficiency, deficient › hormone › growth (isolated)
• Deficiency, deficient › hormone › pituitary
• Deficiency, deficient › pituitary hormone (isolated)
• Dwarfism › hypophyseal
• Dwarfism › Lorain (-Levi) type
• Dwarfism › pituitary
• Eunuchoidism › hypogonadotropic
• Fertile eunuch syndrome
• Hypoadrenocorticism › pituitary
• Hypofunction › pituitary (gland) (anterior)
• Hypogonadism › hypogonadotropic
• Hypogonadism › pituitary
• Hypophyseal, hypophysis › dwarfism
• Hypopituitarism (juvenile)
• Hyposecretion › ACTH
• Infancy, infantile, infantilism › Lorain
• Infancy, infantile, infantilism › pituitary
• Infertility › female › associated with › pituitary-hypothalamic origin
• Insufficiency, insufficient › pituitary
• Kallmann's syndrome
• Lorain (-Levi) short stature syndrome
• Myopathy › in (due to) › hypopituitarism
• Necrosis, necrotic (ischemic) › pituitary (gland)
• Panhypopituitarism
• Panhypopituitarism › prepubertal
• Sheehan's disease or syndrome
• Simmonds' cachexia or disease
• Syndrome › fertile eunuch
• Syndrome › hypopituitarism
• Syndrome › infantilism (pituitary)
• Syndrome › postpartum panhypopituitary (Sheehan)

Nearby codes

• E23 Hypofunction and other disorders of the pituitary gland
• E23.0 Hypopituitarism (this code)
• E23.1 Drug-induced hypopituitarism
• E23.2 Diabetes insipidus
• E23.3 Hypothalamic dysfunction, not elsewhere classified
• E23.6 Other disorders of pituitary gland
• E23.7 Disorder of pituitary gland, unspecified