E23.3 Hypothalamic dysfunction, not elsewhere classified

Billable ICD-10-CM code, FY2026.

Excludes1 (never code together)

• Prader-Willi syndrome (Q87.11)
• Russell-Silver syndrome (Q87.19)

Applies from E23 Hypofunction and other disorders of the pituitary gland

Includes

• the listed conditions whether the disorder is in the pituitary or the hypothalamus

Excludes1 (never code together)

• postprocedural hypopituitarism (E89.3)
• short stature due to endocrine disorder (E34.3-)

Risk adjustment (HCC)

• CMS-HCC V22: HCC 23 — Other Significant Endocrine and Metabolic Disorders
• RxHCC V08: HCC 43 — Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders
• ESRD V24: HCC 23

MS-DRG index

Defines the logic of DRG(s) 643-645 in MDC 10.

Approximate ICD-9-CM (GEMs)

• 253.9 Unspecified disorder of the pituitary gland and its hypothalamic control (approximate)

Code annotations containing back-references to E23.3

Back-references to E23

• Code First: G63 Polyneuropathy in diseases classified elsewhere ("endocrine disease, except diabetes (E00-E07, E15-E16, E20-E34)")

Diagnosis Index entries for E23.3

• Disorder (of) › neurohypophysis NEC
• Dysfunction › hypothalamic NEC
• Dysfunction › pituitary (gland)
• Dyspituitarism
• Overactive › hypothalamus
• Renon-Delille syndrome

Nearby codes

• E23 Hypofunction and other disorders of the pituitary gland
• E23.0 Hypopituitarism
• E23.1 Drug-induced hypopituitarism
• E23.2 Diabetes insipidus
• E23.3 Hypothalamic dysfunction, not elsewhere classified (this code)
• E23.6 Other disorders of pituitary gland
• E23.7 Disorder of pituitary gland, unspecified