E25.0 Congenital adrenogenital disorders associated with enzyme deficiency

Billable ICD-10-CM code, FY2026.

Applicable to

• Congenital adrenal hyperplasia
• 21-Hydroxylase deficiency
• Salt-losing congenital adrenal hyperplasia

Applies from E25 Adrenogenital disorders

Includes

• adrenogenital syndromes, virilizing or feminizing, whether acquired or due to adrenal hyperplasia consequent on inborn enzyme defects in hormone synthesis
• Female adrenal pseudohermaphroditism
• Female heterosexual precocious pseudopuberty
• Male isosexual precocious pseudopuberty
• Male macrogenitosomia praecox
• Male sexual precocity with adrenal hyperplasia
• Male virilization (female)

Excludes1 (never code together)

• indeterminate sex and pseudohermaphroditism (Q56)
• chromosomal abnormalities (Q90-Q99)

Risk adjustment (HCC)

• CMS-HCC V22: HCC 23 — Other Significant Endocrine and Metabolic Disorders
• RxHCC V08: HCC 43 — Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders
• ESRD V24: HCC 23

MS-DRG index

Defines the logic of DRG(s) 643-645 in MDC 10.

Approximate ICD-9-CM (GEMs)

• 255.2 Adrenogenital disorders (approximate)

Code annotations containing back-references to E25.0

Back-references to E25.0

• Type 1 Excludes: E24 Cushing's syndrome ("congenital adrenal hyperplasia (E25.0)")
• Type 1 Excludes: E30.1 Precocious puberty ("congenital adrenal hyperplasia (E25.0)")
• Type 1 Excludes: Q89.1 Congenital malformations of adrenal gland ("congenital adrenal hyperplasia (E25.0)")

Back-references to E25

• Type 1 Excludes: E30.1 Precocious puberty ("female heterosexual precocious pseudopuberty (E25.-)")
• Type 1 Excludes: E30.1 Precocious puberty ("male isosexual precocious pseudopuberty (E25.-)")
• Code First: G63 Polyneuropathy in diseases classified elsewhere ("endocrine disease, except diabetes (E00-E07, E15-E16, E20-E34)")
• Type 1 Excludes: Q56 Indeterminate sex and pseudohermaphroditism ("female pseudohermaphroditism with adrenocortical disorder (E25.-)")
• Type 1 Excludes: Q89.1 Congenital malformations of adrenal gland ("adrenogenital disorders (E25.-)")

Diagnosis Index entries for E25.0

• Adrenogenital syndrome › congenital
• Adrenogenital syndrome › salt loss
• Adrenogenitalism, congenital
• Defect, defective › 3-beta-hydroxysteroid dehydrogenase
• Defect, defective › 11-hydroxylase
• Defect, defective › 21-hydroxylase
• Deficiency, deficient › 3-beta hydroxysteroid dehydrogenase
• Deficiency, deficient › 11-hydroxylase
• Deficiency, deficient › 21-hydroxylase
• Hyperadrenocorticism › congenital
• Hyperfunction › adrenal cortex, not associated with Cushing's syndrome › virilism › congenital
• Hyperplasia, hyperplastic › adrenal (capsule) (cortex) (gland) › with › sexual precocity (male) › congenital
• Hyperplasia, hyperplastic › adrenal (capsule) (cortex) (gland) › with › virilism, adrenal › congenital
• Hyperplasia, hyperplastic › adrenal (capsule) (cortex) (gland) › with › virilization (female) › congenital
• Hyperplasia, hyperplastic › adrenal (capsule) (cortex) (gland) › congenital
• Hyperplasia, hyperplastic › adrenal (capsule) (cortex) (gland) › congenital › salt-losing
• Macrogenitosomia (adrenal) (male) (praecox) › congenital
• Masculinization (female) with adrenal hyperplasia › congenital
• Precocity, sexual (constitutional) (cryptogenic) (female) (idiopathic) (male) › with adrenal hyperplasia › congenital
• Pseudohermaphroditism › female › adrenal (congenital)
• Syndrome › adrenogenital › congenital, associated with enzyme deficiency
• Virilism (adrenal) › congenital
• Virilization (female) (suprarenal) › congenital

Nearby codes

• E25 Adrenogenital disorders
• E25.0 Congenital adrenogenital disorders associated with enzyme deficiency (this code)
• E25.8 Other adrenogenital disorders
• E25.9 Adrenogenital disorder, unspecified