E27.1 Primary adrenocortical insufficiency

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applicable to

• Addison's disease
• Autoimmune adrenalitis

Excludes1 (never code together)

• Addison only phenotype adrenoleukodystrophy (E71.528)
• amyloidosis (E85.-)
• tuberculous Addison's disease (A18.7)
• Waterhouse-Friderichsen syndrome (A39.1)

Risk adjustment (HCC)

• CMS-HCC V28: HCC 51 — Addison's and Cushing's Diseases, Acromegaly, and Other Specified Endocrine Disorders
• CMS-HCC V22: HCC 23 — Other Significant Endocrine and Metabolic Disorders
• RxHCC V08: HCC 43 — Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders
• ESRD V24: HCC 23

MS-DRG index

Defines the logic of DRG(s) 643-645 in MDC 10.

Approximate ICD-9-CM (GEMs)

• 255.41 Glucocorticoid deficiency (approximate)

Code annotations containing back-references to E27.1

Back-references to E27

• Code First: G63 Polyneuropathy in diseases classified elsewhere ("endocrine disease, except diabetes (E00-E07, E15-E16, E20-E34)")

Diagnosis Index entries for E27.1

• Addison's › disease (bronze) or syndrome
• Adrenalitis, adrenitis › autoimmune
• Atrophy, atrophic (of) › adrenal (capsule) (gland) › primary (autoimmune)
• Atrophy, atrophic (of) › suprarenal (capsule) (gland) › primary
• Deficiency, deficient › corticoadrenal › primary
• Disease, diseased › bronze Addison's
• Hypoadrenalism, hypoadrenia › primary
• Hypoadrenocorticism › primary
• Hypofunction › adrenocortical › primary
• Insufficiency, insufficient › adrenal (gland) › primary
• Insufficiency, insufficient › adrenocortical › primary
• Insufficiency, insufficient › corticoadrenal › primary
• Insufficiency, insufficient › suprarenal › primary
• Melanosis › addisonian
• Melanosis › adrenal
• Melanosis › suprarenal
• Melasma › adrenal (gland)
• Melasma › suprarenal (gland)
• Myopathy › in (due to) › Addison's disease

Nearby codes

• E27 Other disorders of adrenal gland
• E27.0 Other adrenocortical overactivity
• E27.1 Primary adrenocortical insufficiency (this code)
• E27.2 Addisonian crisis
• E27.3 Drug-induced adrenocortical insufficiency
• E27.4 Other and unspecified adrenocortical insufficiency
• E27.40 Unspecified adrenocortical insufficiency
• E27.49 Other adrenocortical insufficiency