E27.49 Other adrenocortical insufficiency

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applicable to

• Adrenal hemorrhage
• Adrenal infarction

Applies from E27.4 Other and unspecified adrenocortical insufficiency

Excludes1 (never code together)

• adrenoleukodystrophy [Addison-Schilder] (E71.528)
• Waterhouse-Friderichsen syndrome (A39.1)

Risk adjustment (HCC)

• CMS-HCC V22: HCC 23 — Other Significant Endocrine and Metabolic Disorders
• RxHCC V08: HCC 43 — Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders
• ESRD V24: HCC 23

MS-DRG index

Defines the logic of DRG(s) 643-645 in MDC 10.

Approximate ICD-9-CM (GEMs)

• 255.41 Glucocorticoid deficiency (approximate)
• 255.42 Mineralocorticoid deficiency (approximate)

Code annotations containing back-references to E27.49

Back-references to E27

• Code First: G63 Polyneuropathy in diseases classified elsewhere ("endocrine disease, except diabetes (E00-E07, E15-E16, E20-E34)")

Diagnosis Index entries for E27.49

• Atrophy, atrophic (of) › adrenal (capsule) (gland)
• Atrophy, atrophic (of) › suprarenal (capsule) (gland)
• Calcification › adrenal (capsule) (gland)
• Calcification › suprarenal (capsule) (gland)
• Deficiency, deficient › combined glucocorticoid and mineralocorticoid
• Deficiency, deficient › glucocorticoid
• Deficiency, deficient › glucocorticoid › mineralocorticoid
• Deficiency, deficient › mineralocorticoid
• Deficiency, deficient › mineralocorticoid › with glucocorticoid
• Hemorrhage, hemorrhagic (concealed) › adrenal (capsule) (gland)
• Hemorrhage, hemorrhagic (concealed) › suprarenal (capsule) (gland)
• Infarct, infarction › adrenal (capsule) (gland)
• Infarct, infarction › suprarenal (capsule) (gland)
• Insensitivity › adrenocorticotropin hormone (ACTH)
• Necrosis, necrotic (ischemic) › adrenal (capsule) (gland)
• Necrosis, necrotic (ischemic) › suprarenal (capsule) (gland)

Nearby codes

• E27.1 Primary adrenocortical insufficiency
• E27.2 Addisonian crisis
• E27.3 Drug-induced adrenocortical insufficiency
• E27.4 Other and unspecified adrenocortical insufficiency
• E27.40 Unspecified adrenocortical insufficiency
• E27.49 Other adrenocortical insufficiency (this code)
• E27.5 Adrenomedullary hyperfunction
• E27.8 Other specified disorders of adrenal gland
• E27.9 Disorder of adrenal gland, unspecified