E27.5 Adrenomedullary hyperfunction

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applicable to

• Adrenomedullary hyperplasia
• Catecholamine hypersecretion

Code also

• , if applicable:
• malignant pheochromocytoma (C74.1-)
• pheochromocytoma (benign) (D35.0-)
• secondary hypertension (I15.2)

Risk adjustment (HCC)

• CMS-HCC V22: HCC 23 — Other Significant Endocrine and Metabolic Disorders
• RxHCC V08: HCC 43 — Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders
• ESRD V24: HCC 23

MS-DRG index

Defines the logic of DRG(s) 643-645 in MDC 10.

Approximate ICD-9-CM (GEMs)

• 255.6 Medulloadrenal hyperfunction

Code annotations containing back-references to E27.5

Back-references to E27

• Code First: G63 Polyneuropathy in diseases classified elsewhere ("endocrine disease, except diabetes (E00-E07, E15-E16, E20-E34)")

Diagnosis Index entries for E27.5

• Hyperadrenalism
• Hyperfunction › adrenal cortex, not associated with Cushing's syndrome › medulla
• Hyperfunction › adrenal cortex, not associated with Cushing's syndrome › medulla › adrenomedullary
• Hyperplasia, hyperplastic › adrenomedullary
• Hypersecretion › adrenaline
• Hypersecretion › adrenomedullary
• Hypersecretion › catecholamine
• Hypersecretion › epinephrine
• Hypersecretion › medulloadrenal
• Increase, increased › function › adrenal › medulla
• Overproduction › catecholamine
• Secretion › catecholamine, by pheochromocytoma
• Secretion › hormone › by › pheochromocytoma

Nearby codes

• E27.2 Addisonian crisis
• E27.3 Drug-induced adrenocortical insufficiency
• E27.4 Other and unspecified adrenocortical insufficiency
• E27.40 Unspecified adrenocortical insufficiency
• E27.49 Other adrenocortical insufficiency
• E27.5 Adrenomedullary hyperfunction (this code)
• E27.8 Other specified disorders of adrenal gland
• E27.9 Disorder of adrenal gland, unspecified