E28.0 Estrogen excess

Billable ICD-10-CM code, FY2026.

Use additional code

• code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Applies from E28 Ovarian dysfunction

Excludes1 (never code together)

• isolated gonadotropin deficiency (E23.0)
• postprocedural ovarian failure (E89.4-)

MS-DRG index

Defines the logic of DRG(s) 742-743 in MDC 13.

Approximate ICD-9-CM (GEMs)

• 256.0 Hyperestrogenism

Code annotations containing back-references to E28.0

Back-references to E28

• Code First: G63 Polyneuropathy in diseases classified elsewhere ("endocrine disease, except diabetes (E00-E07, E15-E16, E20-E34)")
• Type 1 Excludes: N91 Absent, scanty and rare menstruation ("ovarian dysfunction (E28.-)")

Diagnosis Index entries for E28.0

• Excess, excessive, excessively › estrogen
• Hyperestrogenism (drug-induced) (iatrogenic)
• Hypersecretion › estrogen
• Increase, increased › estrogen
• Puberty (development state) › precocious (constitutional) (cryptogenic) (idiopathic) › due to › ovarian hyperfunction › estrogen

Nearby codes

• E28 Ovarian dysfunction
• E28.0 Estrogen excess (this code)
• E28.1 Androgen excess
• E28.2 Polycystic ovarian syndrome
• E28.3 Primary ovarian failure
• E28.31 Premature menopause
• E28.310 Symptomatic premature menopause