E28.310 Symptomatic premature menopause

Billable ICD-10-CM code, FY2026.

Applicable to

• Symptoms such as flushing, sleeplessness, headache, lack of concentration, associated with premature menopause

Applies from E28 Ovarian dysfunction

Excludes1 (never code together)

• isolated gonadotropin deficiency (E23.0)
• postprocedural ovarian failure (E89.4-)

Applies from E28.3 Primary ovarian failure

Excludes1 (never code together)

• pure gonadal dysgenesis (Q99.1)
• Turner's syndrome (Q96.-)

MS-DRG index

Defines the logic of DRG(s) 742-743 in MDC 13.

Approximate ICD-9-CM (GEMs)

• 256.31 Premature menopause (approximate)

Medicare Code Edits (MCE v43.1 (April 2026))

• Adult diagnoses (age 15 through 124): Age conflict edit. These diagnoses are clinically expected only in patients age 15 through 124.

Code annotations containing back-references to E28.310

Back-references to E28.310

• Type 1 Excludes: N95.1 Menopausal and female climacteric states ("symptoms associated with premature menopause (E28.310)")

Back-references to E28.31

• Type 1 Excludes: N95 Menopausal and other perimenopausal disorders ("menopausal and perimenopausal disorders due to artificial or premature menopause (E89.4-, E28.31-)")
• Type 1 Excludes: N95 Menopausal and other perimenopausal disorders ("premature menopause (E28.31-)")
• Code Also: Z91.B Personal risk factor of exposure to diethylstilbestrol ("premature menopause (E28.31-)")

Back-references to E28

• Code First: G63 Polyneuropathy in diseases classified elsewhere ("endocrine disease, except diabetes (E00-E07, E15-E16, E20-E34)")
• Type 1 Excludes: N91 Absent, scanty and rare menstruation ("ovarian dysfunction (E28.-)")

Diagnosis Index entries for E28.310

• Menopause, menopausal (asymptomatic) (state) › premature › symptomatic
• Premature › menopause › symptomatic

Nearby codes

• E28.0 Estrogen excess
• E28.1 Androgen excess
• E28.2 Polycystic ovarian syndrome
• E28.3 Primary ovarian failure
• E28.31 Premature menopause
• E28.310 Symptomatic premature menopause (this code)
• E28.319 Asymptomatic premature menopause
• E28.39 Other primary ovarian failure
• E28.8 Other ovarian dysfunction
• E28.9 Ovarian dysfunction, unspecified