E31.1 Polyglandular hyperfunction

Billable ICD-10-CM code, FY2026.

Excludes1 (never code together)

• multiple endocrine adenomatosis (E31.2-)
• multiple endocrine neoplasia (E31.2-)

Applies from E31 Polyglandular dysfunction

Excludes1 (never code together)

• ataxia telangiectasia [Louis-Bar] (G11.3)
• dystrophia myotonica [Steinert] (G71.11)
• pseudohypoparathyroidism (E20.1)

Risk adjustment (HCC)

• CMS-HCC V28: HCC 51 — Addison's and Cushing's Diseases, Acromegaly, and Other Specified Endocrine Disorders
• CMS-HCC V22: HCC 23 — Other Significant Endocrine and Metabolic Disorders
• RxHCC V08: HCC 43 — Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders
• ESRD V24: HCC 23

MS-DRG index

Defines the logic of DRG(s) 643-645 in MDC 10.

Approximate ICD-9-CM (GEMs)

• 258.8 Other specified polyglandular dysfunction (approximate)

Code annotations containing back-references to E31.1

Back-references to E31

• Code First: G63 Polyneuropathy in diseases classified elsewhere ("endocrine disease, except diabetes (E00-E07, E15-E16, E20-E34)")

Diagnosis Index entries for E31.1

• Hyperfunction › polyglandular

Nearby codes

• E31 Polyglandular dysfunction
• E31.0 Autoimmune polyglandular failure
• E31.1 Polyglandular hyperfunction (this code)
• E31.2 Multiple endocrine neoplasia [MEN] syndromes
• E31.20 Multiple endocrine neoplasia [MEN] syndrome, unspecified
• E31.21 Multiple endocrine neoplasia [MEN] type I
• E31.22 Multiple endocrine neoplasia [MEN] type IIA
• E31.23 Multiple endocrine neoplasia [MEN] type IIB